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Beta-Sheet Breaker Peptide iAβ5

Catalog No.
A1005
Peptide which can inhibit amyloidogenesis
Grouped product items
SizePriceStock Qty
5mg
$45.00
In stock
10mg
$75.00
In stock
25mg
$105.00
In stock

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Background

Beta-Sheet Breaker Peptide iAβ5 (C33H43N5O8), with the sequence H-Leu-Pro-Phe-Phe-Asp-OH, has been shown to inhibit amyloidogenesis in rat brain models. Research showed that beta-sheet breaker peptide significantly reduces amyloid beta-protein deposition in vivo and completely blocks the formation of amyloid fibrils in a rat brain model of amyloidosis. Current evidence supports the notion that beta-amyloid deposits or Abeta intermediates may be responsible for the pathogenesis in Alzheimer’s disease (AD) patients. Because of its inhibition of cerebral amyloid beta-protein deposition, Beta-Sheet Breaker Peptide seems to be an important target for Alzheimer's disease therapy.

Ref:

1. C. Soto, E.M. Sigurdsson, L. Morelli, R.A. Kumar, E.M. Castano, and B. Frangione, Nat. Med., 4, 822 (1998) (Original; Pharmacol.)

2. MA Chacon, MI Barria, C Soto and NC Inestrosa. Beta-sheet breaker peptide prevents Abeta-induced spatial memory impairments with partial reduction of amyloid deposits.

 

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt637.73
Cas No.182912-74-9
FormulaC33H43N5O8
SynonymsH2N-Leu-Pro-Phe-Phe-Asp-OH
Solubility≥63.7mg/mL in DMSO
SDFDownload SDF
Canonical SMILESN[[email protected]@H](CC(C)C)C(N1[[email protected]@H](CCC1)C(N[[email protected]@H](CC2=CC=CC=C2)C(N[[email protected]@H](CC3=CC=CC=C3)C(N[[email protected]@H](CC(O)=O)C(O)=O)=O)=O)=O)=O
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Quality Control

Quality Control & MSDS

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Chemical structure

Beta-Sheet Breaker Peptide iAβ5