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Acetaminophen

Catalog No.
B3532
COX inhibitor
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$55.00
In stock
5g
$42.00
In stock
10g
$57.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Acetaminophen (paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with IC50 of 25.8 μM, It is a widely used antipyretic analgesic[1].

Paracetamol (50 mM) significantly reduces cell viability. But co-treatment with acetaminophen and HV110 can significantly increase cell viability[2].

Paracetamol (250 mg / kg) reduces glutathione levels and glutathione peroxidase activity in mice, and induces mast cell death and hypertrophy in primary mouse liver cells The inhibitor ferrostatin-1 can block this effect. Paracetamol has analgesic and antipyretic effects in animal models.

References:

[1]. Hinz, B, et al. Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man, 2008, 22(2): 383-90.

[2]. Dini M, et al. Lactobacillus fermentum Postbiotic-induced Autophagy as Potential Approach for Treatment ofAcetaminophen Hepatotoxicity. Front Microbiol, 2017, 8: 594.

[3]. Lőrincz T, Jemnitz K, Kardon T, et al. Ferroptosis is Involved in Acetaminophen Induced Cell Death. Pathology & Oncology Research, 2015, 21(4): 1115-1121.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt151.16
Cas No.103-90-2
FormulaC8H9NO2
Solubility≥7.56mg/mL in DMSO
Chemical Name(Z)-N-(4-hydroxyphenyl)acetimidic acid
SDFDownload SDF
Canonical SMILESC/C(O)=N/C1=CC=C(O)C=C1
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control