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Hedgehog

Hh (Hedgehog) signalling is a evolutionarily conserved pathway that is critical for embryonic development, tissue and organ morphogenesis. Mammalian Hh protein ligands include Sonic Hh, Desert Hh and Indian Hh. Dysfunctions of Hh singalling lead to developmental abnormalities and cancer.

Items 11-20 of 21

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  1. Jervine
    A8656 Jervine
    Summary: Hedgehog signaling Inhibitor
      ≥14.55 mg/mL
  2. AY 9944 dihydrochloride
    A8658 AY 9944 dihydrochloride
    Summary: Hedgehog Inhibitor
      Soluble in H2O
  3. SANT-1
    A8659 SANT-1
     1 Citation
    Summary: Shh inhibitor,potent and cell-permeable
      insoluble in H2O; insoluble in EtOH; ≥18.75 mg/mL
  4. SAG
    B5837 SAG
    Summary: Hh and Smo agonist
      ≥24.5 mg/mL
  5. U 18666A
    B6812 U 18666A
    Summary: inhibitor of cholesterol transport and synthesis
      Soluble in H2O
  6. 20(S)-Hydroxycholesterol
    B7669 20(S)-Hydroxycholesterol
    Summary: Allosteric activator of the Hedgehog signaling pathway Smoothened (Smo) oncoprotein
      Soluble in ethanol
  7. GDC-0449 (Vismodegib)
    A3021 GDC-0449 (Vismodegib)
     1 Citation
    Target: P-glycoprotein (P-gp)|Hedgehog
    Summary: Hedgehog antagonist,potent and selective
      ≥21.08 mg/mL
  8. GANT 58
    A3429 GANT 58
    Summary: GLI antagonist,novel and potent
  9. MK-4101
    B7803 MK-4101
    Summary: Hedgehog (Hh) signaling pathway inhibitor
      Soluble in DMSO
  10. Oxy-16
    C5136 Oxy-16
    Summary: antagonist of hedgehog activity
      ≤10 mg/mL

Items 11-20 of 21

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