DCA
Catalog No.
B7174
mitochondrial pyruvate dehydrogenase kinase (PDK) inhibitor
Featured Products
Dichloroacetate (DCA; CAS 2156-56-1) is a small molecule inhibitor targeting pyruvate dehydrogenase kinase (PDK) isoforms. It inhibits PDK2 and PDK4 with IC50 values of 183 μM and 80 μM, respectively, activating pyruvate dehydrogenase and altering cancer cell metabolism. Treatment with DCA elevates reactive oxygen species levels, inducing mitochondrial membrane depolarization and apoptosis in cancer cells. In murine melanoma xenograft models, DCA administration reduced tumor size, weight, and volume, prolonged survival, and suppressed metastasis. DCA is widely investigated in oncology research focused on metabolic modulation and apoptosis.
- 1. Mengqi Li, Yanyu Ma, et al. "Hypoxia Promotes the In Vitro Proliferation of Buffalo Spermatogonial Cells by Increasing Lactate and H3K18la Lactylation Levels." Cells. 2025 Jun 3;14(11):832 PMID: 40498008
- 2. He Y, Ji Z, et al. "Numb/Parkin-directed mitochondrial fitness governs cancer cell fate via metabolic regulation of histone lactylation." Cell Rep 2023 Jan 30;42(2) PMID: 36724072
| Physical Appearance | A solid |
| Storage | Desiccate at RT |
| M.Wt | 150.92 |
| Cas No. | 2156-56-1 |
| Formula | C2HCl2NaO2 |
| Solubility | ≥15.1 mg/mL in DMSO with gentle warming; ≥46.3 mg/mL in EtOH; ≥62.7 mg/mL in H2O |
| Chemical Name | sodium 2,2-dichloroacetate |
| SDF | Download SDF |
| Canonical SMILES | ClC(C([O-])=O)Cl.[Na+] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
