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Catalog No.
L3MBTL antagonist,potent and selective
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
In stock
In stock
In stock

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UNC 669 is a potent antagonist of L3MBTL1 (IC50=4.2 μM) and L3MBTL3 (IC50=3.1 μM).

There is less bio-data supported for UNC669. UNC1679 is an analog of UNC669. UNC1215 is the first potent and selective antagonism of a methyl-lysine reader protein, L3MBTL3, which antagonizes the mono- and dimethyl-lysine reading function of L3MBTL3. [1]

Lysine methylation is a key epigenetic landmark, the dysregulation of which is related to many diseases. UNC1679 maintains in vitro and cellular potency with improved selectivity against other MBT-containing proteins. The antagonists described were also found to effectively interact with unlabeled endogenous L3MBTL3 in cells. [1]

1.  James LI, Korboukh VK, Krichevsky L et al. Small-molecule ligands of methyl-lysine binding proteins: optimization of selectivity for L3MBTL3. J Med Chem. 2013 Sep 26;56(18):7358-71. doi: 10.1021/jm400919p. Epub 2013 Sep 16.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
Cas No.1314241-44-5
Solubility≥9.35mg/mL in DMSO
Chemical Name(5-bromopyridin-3-yl)-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone
SDFDownload SDF
Canonical SMILESC1CCN(C1)C2CCN(CC2)C(=O)C3=CC(=CN=C3)Br
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Biological Activity

Description UNC669 is a potent antagonist of L3MBTL with IC50 values of 4.2 µM and 3.1 µM for L3MBTL1 and L3MBTL3, respectively.
Targets L3MBTL1 L3MBTL3        
IC50 4.2 µM 3.1 µM        

Quality Control

Chemical structure