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Histone Methyltransferase

Histone methyltransferases are a group of enzymes that catalyze the methylation of histone lysine and arginine by adding methyl groups to specific histone arginine or lysine residues. Histone methyltransferaes can be classified into 3 classes, including SET domain lysine methyltransferases, non-SET domain lysine methyltransferases and arginine methyltransferases (PRMTs), all of which use S-adenosylmethionine as a cosubstrate for the transfer of the methyl group. Aberrant histone methylation has been associated with a wide range of human cancers (such as hematological malignancies), which leads to the development of novel cancer chemotherapies targeting cancer-associated histone methyltransferases (more than 20 lysine methyltransferases and 9 arginine methyltransferases in humans).

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  1. Cat.No. Product Name Information
  2. B7718 (R)-PFI 2 hydrochloride SETD7 histone lysine methyltransferase inhibitor
  3. C4834 (S)-PFI-2 (hydrochloride) Negative control of (R)-PFI 2 hydrochloride
  4. A8182 3-Deazaneplanocin A (DZNep) hydrochloride SAHH and ENZ2 inhibitor
  5. A1905 3-Deazaneplanocin,DZNep S-adenosylhomocysteine and EZH2 inhibitor
  6. B4947 A 366 G9a/GLP histone lysine methyltransferase inhibitor
  7. B6120 Adox indirect methyltransferase inhibitor
  8. A1908 AMI-1 PRMT1 inhibitor
  9. B6085 AMI5/Eosin Y disodium salt Dye/protein methyltransferase inhibitor
  10. B1255 AZ505 SMYD2 inhibitor,potent and selective
  11. B1256 AZ505 ditrifluoroacetate SMYD2 inhibitor

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