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Bcl-2 Family

Bcl-2 family proteins are a group of proteins homologous to the Bcl-2 protein and characterized by containing at least one of four conserved Bcl-2 homology (BH) domains (BH1, BH2, BH3 and BH4). Bcl-2 family proteins, consisting of pro-apoptotic and anti-apoptotic molecules, can be classified into the following three subfamilies according to sequence homology within four BH domains: (1) a subfamily shares sequence homology within all four BH domains, such as Bcl-2, Bcl-XL and Bcl-w which are anti-apoptotic; (2) a subfamily shares sequence homology within BH1, BH2 and BH4, such as Bax and Bak which are pro-apoptotic; (3) a subfamily shares sequence homology only within BH3, such as Bik and Bid which are pro-apoptotic.

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Biochemicals

  1. Cat.No. Product Name Information
  2. A3935 WEHI-539 Bcl-xL inhibitor,potent and selective
  3. B6094 BH3I-1 Bcl-2 or Bcl-XL inhibitor
  4. A8737 S63845 MCL1 inhibitor
  5. B6011 A-1210477 MCL-1 inhibitor
  6. B5978 BDA-366 Selective antagonist of BCL2 BH4 domain
  7. B5846 Radotinib(IY-5511) Bcr-Abl tyrosine kinase inhibitor
  8. B4902 (+)-Apogossypol inhibitor of Bcl-2 family proteins
  9. B4901 Pyridoclax Mcl-1 inhibitor
  10. B4881 UMI-77 Mcl-1 inhibitor, novel
  11. A8194 ABT-199 Bcl-2 inhibitor,potent and selective
  12. A8193 ABT-737 Top Seller Bcl-2 inhibitor
  13. A3007 ABT-263 (Navitoclax) Potent Bcl-2 family inhibitor, inhibits Bcl-2, Bcl-xL, and Bcl-w
  14. A4234 TW-37 Top Seller Bcl-2 inhibitor, inhibits Bcl-2,Bcl-XL and Mcl-1
  15. A9902 Bcl Family Set I Bcl family inhibitors
  16. A4194 Obatoclax mesylate (GX15-070) Potent Bcl-2 inhibitor
  17. A8168 HA14-1 Top Seller Bcl-2 inhibitor,potent and cell-permeable
  18. B1080 Marinopyrrole A Selective Mcl-1 inhibitor
  19. A4461 Bax inhibitor peptide V5 Bax inhibitor
  20. A4460 Bax inhibitor peptide P5 Bax inhibitor
  21. A3218 BAM7 BAX activator,direct and selective
  22. A4199 Sabutoclax pan-Bcl-2 inhibitor
  23. A4200 Apogossypolone (ApoG2) Bcl-2 inhibitor,nonpeptidic small molecule
  24. A4198 BM-1074 Bcl-2/Bcl-xL inhibitor,potent and selective
  25. A4459 Bax channel blocker Inhibitor of Bax-mediated mitochondrial cytochrome c release
  26. A4462 Bax inhibitor peptide, negative control Peptide inhibit Bax translocation to mitochondria
  27. A4463 BIM, Biotinylated Bim peptide fragment with a biotin moiety attached
  28. A4464 iMAC2 MAC inhibitor
  29. A4465 MIM1 Mcl-1 Inhibitor
  30. A4466 Muristerone A TRAIL- and hFasL-induced apoptosis inhibitor
  31. N2135 Gossypol PAF inhibitor;anti-fertility and anti-cancer
  32. A4447 2,3-DCPE hydrochloride Bcl-XL protein expression downregulator
  33. A3196 AT-101 BH3-mimetic,gossypol enantiomer
  34. A3424 Gambogic Acid Caspase activator and apoptosis inducer
  35. B4691 Mcl1-IN-1 Myeloid cell factor 1 inhibitor