U-104|CAIX inhibitor|CAS# 178606-66-1

Home >> Signaling Pathways >> Metabolism >> Carbonic Anhydrase >> U-104

Size	Price	Stock
10mM (in 1mL DMSO)	$50.00	In stock
10mg	$50.00	In stock
25mg	$105.00	In stock
50mg	$190.00	In stock

Publications citing ApexBio Products

Nature.
2017 Jan 19;541(7637):417-420.

Nature.
2016 Apr 21;532(7599):398-401.

Science.
2016 Aug 5;353(6299)594-8

Nature Biotechnology.
2017 Jun;35(6):569-576

Cell.
2017 Jul 13;170(2):312-323

Cell.
2017 Apr 6;169(2):286-300.

Cell.
2015 Aug 27;162(5):987-1002.

Cell.
2015 Feb 12;160(4):729-44.

Nature Medicine.
2017 Apr;23(4):493-500.

Cancer Cell.
2017 May 8;31(5):635-652.e6.

Immunity.
2016 Jan 19;44(1):88-102

Nat Cell Biol.
2015 May;17(5):627-38.

Nat Immunol.
2017 Jun;18(6):654-664.

Nat Neurosci.
2015 Oct;18(10):1464-73.

Cell Res.
2016 Sep;26(9):1007-20.

Mol Cell.
2017 May 18;66(4):546-557.

Mol Cell.
2017 Jun 1;66(5):698-710.

Mol Cell.
2017 Mar 2;65(5):941-955.e8.

Nat Commun.
2016 Feb 1;7:10492.

J Cell Biol.
2016 Apr 11;213(1):109-25.

Cell Host Microbe.
2016 Jul 13;20(1):13-24.

Proc Natl Acad Sci U S A.
2016 Mar 8;113(10):2585-90.

Proc Natl Acad Sci U S A.
2015 Jun 30;112(26):E3365-73.

Proc Natl Acad Sci U S A.
2015 Jul 28;112(30):9412-7.

Autophagy.
2016 Jul 2;12(7):1129-52.

Cancer Res canres.
2946.2015.

Elife.
2016 Jan 14;5. pii: e12203.

Nucleic Acids Res.
2016 Feb 18;44(3):e2.

EMBO Rep.
2015 Sep;16(9):1114-30.

Oncogene.
2016 Mar 21.

Cell Rep.
2015 Sep 29;12(12):1986-96.

Cell Death Differ.
2016 Jun;23(6):1026-37.

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Quality Control

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Purity = 99.32%

Chemical structure

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Chemical Properties

Cas No.	178606-66-1	SDF	Download SDF
Chemical Name	1-(4-fluorophenyl)-3-(4-sulfamoylphenyl)urea
Canonical SMILES	C1=CC(=CC=C1NC(=O)NC2=CC=C(C=C2)S(=O)(=O)N)F
Formula	C₁₃H₁₂FN₃O₃S	M.Wt	309.32
Solubility	>11.5mg/mL in DMSO	Storage	Store at -20°C
General tips	N/A
Shipping Condition	N/A

Background

U-104 is a novel ureido-sulfonamide inhibitor of Carbonic Anhydrase IX (CAIX). Tumor volume measurements show important inhibition of primary tumor growth in the mice treated with the U-104 compound compared with vehicle controls. It also has ability to inhibit metastasis formation in the 4T1 experimental metastasis model.

Reference

Yuanmei Lou, Paul C. McDonald, Arusha Oloumi, Stephen Chia, Christina Ostlund, Ardalan Ahmadi, Alastair Kyle, Ulrich auf dem Keller, Samuel Leung, David Huntsman, Blaise Clarke, Brent W. Sutherland, Dawn Waterhouse, Marcel Bally, Calvin Roskelley, Christopher M. Overall, Andrew Minchinton, Fabio Pacchiano, Fabrizio Carta, Andrea Scozzafava, Nadia Touisni, Jean-Yves Winum, Claudiu T. Supuran, Shoukat Dedhar. Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors. Cancer Research May 1, 2011 71; 3364