U-104
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
U-104 is a novel ureido-sulfonamide inhibitor of Carbonic Anhydrase IX (CAIX). Tumor volume measurements show important inhibition of primary tumor growth in the mice treated with the U-104 compound compared with vehicle controls. It also has ability to inhibit metastasis formation in the 4T1 experimental metastasis model.
Reference
Yuanmei Lou, Paul C. McDonald, Arusha Oloumi, Stephen Chia, Christina Ostlund, Ardalan Ahmadi, Alastair Kyle, Ulrich auf dem Keller, Samuel Leung, David Huntsman, Blaise Clarke, Brent W. Sutherland, Dawn Waterhouse, Marcel Bally, Calvin Roskelley, Christopher M. Overall, Andrew Minchinton, Fabio Pacchiano, Fabrizio Carta, Andrea Scozzafava, Nadia Touisni, Jean-Yves Winum, Claudiu T. Supuran, Shoukat Dedhar. Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors. Cancer Research May 1, 2011 71; 3364
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 309.32 |
| Cas No. | 178606-66-1 |
| Formula | C13H12FN3O3S |
| Solubility | ≥11.5 mg/mL in DMSO, ≥9.14 mg/mL in EtOH with ultrasonic and warming,insoluble in H2O |
| Chemical Name | 1-(4-fluorophenyl)-3-(4-sulfamoylphenyl)urea |
| SDF | Download SDF |
| Canonical SMILES | C1=CC(=CC=C1NC(=O)NC2=CC=C(C=C2)S(=O)(=O)N)F |
| Shipping Condition | Evaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request. |
| General tips | For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months. |
Quality Control & MSDS
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Chemical structure
