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Thiostrepton

In stock
Catalog No.
B7336
Antibiotic that inhibits bacterial protein synthesis
Grouped product items
SizePriceStock Qty
50mg
$64.00
Ship with 7 days

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Background

Thiazole antibiotic thiostrepton is an inhibitor of Forkhead box M1 (FOXM1), which effectively reduces cancer cell growth through downregulation of FOXM1. FOXM1 is a transcription factors that regulate expression of genes involved in maintenance of genomic stability and cell cycle progression.

In vitro: Thiostrepton inhibits the transcriptional activity and FOXM1 expression, and induces strong apoptosis in human cancer cells of different origin that correlates with suppression of FOXM1, including leukemia, neuroblastoma, liver cancer, melanoma and prostate cancer cells. Thiostrepton binds FOXM1 on the promoter site to inhibit transcriptional activity of FOXM1 through the FOXM1 autoregulation mechanism [1].

In vivo: Thiostrepton suppressed tumor growth in a human breast cancer xenograft model. Treatment with developed micelle-thiostrepton nanoparticles decreased xenograft tumor growth induced by the human MDA-MB-231 breast and HepG2 liver cancer cell lines. These apoptosis activities in drug-treated tumors were correlated with in vivo suppression of oncogenic FOXM1 [1].

Clinical trial: So far, no clinical study has been conducted.

Reference:
[1] Gartel AL.  Suppression of the Oncogenic Transcription Factor FOXM1 by Proteasome Inhibitors. Scientifica (Cairo). 2014;2014:596528.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt1664.89
Cas No.1393-48-2
FormulaC72H85N19O18S5
SolubilitySoluble in DMSO
SDFDownload SDF
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Quality Control

Quality Control & MSDS

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Chemical structure

Thiostrepton