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SR 3576

Catalog No.
JNK3 inhibitor, potent and selective
Grouped product items
SizePriceStock Qty
Ship with 5-10 days
Ship with 5-10 days

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Product Citation

Chemical Properties

Physical AppearanceOff White solid
StorageStore at -20°C
Cas No.1164153-22-3
Solubility<50.15mg/ml in DMSO
Chemical Name3-(4-(3-(m-tolyl)ureido)-1H-pyrazol-1-yl)-N-(3,4,5-trimethoxyphenyl)benzamide
SDFDownload SDF
Canonical SMILESO=C(C1=CC(N2N=CC(NC(NC3=CC=CC(C)=C3)=O)=C2)=CC=C1)NC(C=C4OC)=CC(OC)=C4OC
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.


Cell experiment[1]:

Cell lines

Human ovarian cancer cisplatin-resistant SKOV3/DDP cells

Preparation method

The solubility of this compound in DMSO is > 10 mM. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.

Reacting condition

24 h, 2 μM


SR 3576 is a specific inhibitor of JNK3. Inhibition of JNK3 by SR 3576 exacerbates oxidative stress and suppresses autophagic flux, resulting in an increase of apoptosis induced by S1 in human ovarian cancer SKOV3/DDP cells.


[1]. Yang X, Xiang X, Xia M, et al. Inhibition of JNK3 promotes apoptosis induced by BH3 mimetic S1 in chemoresistant human ovarian cancer cells[J]. The Anatomical Record, 2015, 298(2): 386-395.

Quality Control

Quality Control & MSDS

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Chemical structure

SR 3576

Related Biological Data

SR 3576