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SIN-1 chloride

Catalog No.
inhibitor of platelet aggregation
Grouped product items
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SIN-1 chloride is an active metabolite of molsidomine, which is a potent vasorelaxant and inhibitor of platelet aggregation. It produces both NO and superoxide and can therefore be used to generate peroxynitrite under physiological conditions. SIN-1 decreases myocardial necrosis and reperfusion-induced endothelial dysfunction in models of myocardial ischemia-reperfusion[1,2]. 


[1]. Rosenkranz B, Winkelmann B R, Parnham M J. Clinical pharmacokinetics of molsidomine. Clinical Pharmacokinetics, 1996, 30(5): 372-384.

[2]. Lomonosova E E, Kirsch M, Rauen U, et al. The critical role of hepes in SIN-1 cytotoxicity, peroxynitrite versus hydrogen peroxide. Free Radical Biology & Medicine, 1998, 24(4): 522-528.

Chemical Properties

StorageStore at -20°C
Cas No.16142-27-1
SolubilitySoluble to 100 mM in sterile water
Chemical Name5-imino-3-morpholino-5H-1,2,3-oxadiazol-3-ium-2-ide hydrochloride
SDFDownload SDF
Canonical SMILESN=C1C=N(N2CCOCC2)=NO1.Cl
Shipping ConditionShip with blue ice, or upon other requests.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

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Chemical structure

SIN-1 chloride