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Poly(I:C) Toll-like receptor 3 (TLR3) agonist

Catalog No.B5551
Size Price Stock Qty
10mM (in 1mL H2O)
$50.00
In stock
10mg
$97.00
In stock
50mg
$412.00
In stock

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Email: [email protected]

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Sample solution is provided at 25 µL, 10mM.

Quality Control

Quality Control & MSDS

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Chemical structure

Poly(I:C)

Protocol

Cell experiment [1]:

Cell lines

Dendritic cell

Preparation method

Soluble in sterile water. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.

Reacting condition

12.5 mg/ml, 3 days

Applications

Treatment of immature DC for 72 h with poly(I:C) resulted in the typical DC morphology and induced significant maturation. Poly(I:C)-treated DC remained stable in phenotype after cytokine withdrawal. Poly(I:C)-treated DC down-regulated pinocytic activity. Poly(I:C)-treated DC produced high levels of IL-12 and low levels of IL-10.

Other notes

Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.

References:

[1]. Verdijk R M, Mutis T, Esendam B, et al. Polyriboinosinic polyribocytidylic acid (poly (I: C)) induces stable maturation of functionally active human dendritic cells[J]. The Journal of Immunology, 1999, 163(1): 57-61.

Poly(I:C) Dilution Calculator

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Chemical Properties

Cas No. 24939-03-5 SDF Download SDF
Synonyms N/A
Chemical Name ((2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-3H-purin-9(6H)-yl)tetrahydrofuran-2-yl)methyl dihydrogen phosphate compound with ((2R,3S,4S,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate (1:1)
Canonical SMILES O[[email protected]@H]([[email protected]](N1C(NC=NC2=O)=C2N=C1)O[[email protected]@H]3COP(O)(O)=O)[[email protected]@H]3O.O[[email protected]]([[email protected]@H](COP(O)(O)=O)O[[email protected]]4N5C=CC(N)=NC5=O)[[email protected]@H]4O
Formula C19H27N7O16P2 M.Wt 671.41
Solubility ≥21.5mg/mL in H2O, <0.4mg/mL in DMSO Storage Store at -20°C
Physical Appearance A solid Shipping Condition Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.