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Poly(I:C)

In stock
Catalog No.
B5551
Toll-like receptor 3 (TLR3) agonist
Grouped product items
SizePriceStock Qty
10mM (in 1mL H2O)
$50.00
In stock
10mg
$97.00
In stock
50mg
$412.00
In stock

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Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt671.41
Cas No.24939-03-5
FormulaC19H27N7O16P2
Solubility≥21.5mg/mL in H2O, <0.4mg/mL in DMSO
Chemical Name((2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-3H-purin-9(6H)-yl)tetrahydrofuran-2-yl)methyl dihydrogen phosphate compound with ((2R,3S,4S,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate (1:1)
SDFDownload SDF
Canonical SMILESO[[email protected]@H]([[email protected]](N1C(NC=NC2=O)=C2N=C1)O[[email protected]@H]3COP(O)(O)=O)[[email protected]@H]3O.O[[email protected]]([[email protected]@H](COP(O)(O)=O)O[[email protected]]4N5C=CC(N)=NC5=O)[[email protected]@H]4O
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Protocol

Cell experiment [1]:

Cell lines

Dendritic cell

Preparation method

Soluble in sterile water. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.

Reacting condition

12.5 mg/ml, 3 days

Applications

Treatment of immature DC for 72 h with poly(I:C) resulted in the typical DC morphology and induced significant maturation. Poly(I:C)-treated DC remained stable in phenotype after cytokine withdrawal. Poly(I:C)-treated DC down-regulated pinocytic activity. Poly(I:C)-treated DC produced high levels of IL-12 and low levels of IL-10.

Other notes

Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.

References:

[1]. Verdijk R M, Mutis T, Esendam B, et al. Polyriboinosinic polyribocytidylic acid (poly (I: C)) induces stable maturation of functionally active human dendritic cells[J]. The Journal of Immunology, 1999, 163(1): 57-61.

Quality Control

Quality Control & MSDS

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Chemical structure

Poly(I:C)