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Neuregulin/Heregulin-1β (NRG-1β/HRG-1β), human recombinant protein

Catalog No.
P1054
NRG-1β/HRG-1β, neurotrophin, expressed in E.Coli.
Grouped product items
SizePriceStock Qty
10ug
$118.00
Ship with 5-10 days
50ug
$264.00
Ship with 5-10 days
1mg
$3,881.00
Ship with 5-10 days

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Neuregulin (NRG) is a signaling protein for ErbB2/ErbB4 receptor heterodimers on the cardiac muscle cells and plays an important role in heart structure and function through inducing cardiomyocyte differentiation. Neuregulin/Heregulin is a family of structurally related polypeptide growth factors derived from alternatively spliced genes (NRG1, NRG2, NRG3 and NRG4). HRG1-β1 contains an Ig domain and an EGF-like domain that is necessary for direct binding to receptor tyrosine kinases ErbB3/ErbB4, which induces ErbB3 and ErbB4 heterodimerization with ErbB2 and leads to tyrosine phosphorylation. HRG1-β1 is involved in up-regulation of expression and function of the autocrine motility-promoting factor (AMF).

Recombinant human Heregulin-β1 (HRG1-β1) is a 7.5 kDa polypeptide consisting of only the EGF domain of heregulin-β1 (65 amino acid residues).

Biological Activity

Determined by the dose-dependent stimulation of the proliferation of human MCF-7 cells.
ED50 < 0.5 ng/ml.          
Specific activity > 2*106 units/mg.          

Quality Control

Quality Control & DataSheet

View current batch:
    Purity: ≥98%, by SDS-PAGE and HPLC.
    Endotoxin Level:< 0.1 ng/μg

Related Biological Data

FGF-21
 

Description

Gene ID: 3084 Accession #: Q15491
Alternate Names:NGR beta 1, Heregulin, HRG 1beta, Neuregulin, Neuregulin1 (NRG1-β1), Neu differentiation factor, Pro-neuregulin-1, Acetylcholine receptor-inducing activity, Breast cancer cell differentiation factor p45, Glial growth factor, Heregulin, Neu differentiation factor, Sensory and motor neuron-derived factor.
Source: Escherichia Coli. M.Wt: 7.86 kDa
Appearance: Lyophilized protein Storage: Store at -20°C
Formulation:Sterile Filtered lyophilized (freeze-dried) powder.
Solubility:Reconstitute in water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or -20°C for future use.
Shipping Condition: Gel pack. Handling: Centrifuge the vial prior to opening.
Usage:For Research Use Only! Not to be used in humans.