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Losartan

Losartan

Catalog No.

B1072

Angiotensin II receptor antagonist

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Grouped product items
Size	Price	Stock	Qty
1g	$50.00	In stock
5g	$120.00	In stock

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background
Chemical Properties
Protocol
Quality Control

Background

Losartan is an angiotensin II receptor antagonist, competes with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.

Chemical Properties

Physical Appearance	A solid
Storage	Store at -20°C
M.Wt	422.91
Cas No.	114798-26-4
Formula	C₂₂H₂₃ClN₆O
Solubility	≥2.48 mg/mL in H2O with gentle warming and ultrasonic; ≥2.9 mg/mL in EtOH with gentle warming; ≥84.6 mg/mL in DMSO
Chemical Name	[2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol
SDF	Download SDF
Canonical SMILES	CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)CO)Cl
Shipping Condition	Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips	We do not recommend long-term storage for the solution, please use it up soon.

Protocol

Cell experiment:[1]
Cell lines	Vascular smooth muscle cells (VSMCs)
Reaction Conditions	0, 1, 5, 10 μM losartan for 48 h incubation
Applications	Losartan dose-dependently decreased the angiotensin Ⅱ (Ang Ⅱ)- or 15% fetal bovine serum (FBS)-induced VSMC proliferation by inhibiting the expression of cell cycle associated proteins, such as p-Rb, cyclin D, and cyclin E.
Animal experiment:[2]
Animal models	Wistar-Kyoto (WKY) rats and stroke-prone, spontaneously hypertensive rats (SHR-SP)
Dosage form	10 mg/kg/day Administered by oral route for 2 weeks
Applications	In SHR-SP, losartan decreased systolic blood pressure, increased the number of circulating endothelial progenitor cells (EPCs) and colony formation, and inhibited oxidation. In addition, losartan was able to stimulated EPC migration. These data suggest that losartan can improve the proliferation and function of EPCs in hypertension, with the potential to repair hypertensive vascular injuries.
Note	The technical data provided above is for reference only.
	References: 1. Kim JE, Choi HC. Losartan inhibits vascular smooth muscle cell proliferation through activation of AMP-activated protein kinase. The Korean Journal of Physiology & Pharmacology, 2010, 14(5): 299-304. 2. Yao EH, Fukuda N, Matsumoto T, et al. Losartan improves the impaired function of endothelial progenitor cells in hypertension via an antioxidant effect. Hypertension Research, 2007, 30(11): 1119-1128.

Quality Control

Quality Control & MSDS

View current batch:

Purity = 99.18%

Chemical structure

Losartan