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Etonogestrel steroidal progestin

Catalog No.B3470
Size Price Stock Qty
10mM (in 1mL DMSO)
$60.00
In stock
5mg
$60.00
In stock
10mg
$77.00
In stock
50mg
$310.00
In stock
100mg
$480.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Protocol

Cell experiment[1]:

Cell lines

human endometrial stromal cells

Preparation method

The solubility of this compound in DMSO is > 10 mM. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.

Reacting condition

7 days, 100 nM

Applications

Etonogestrel is the active metabolite of prodrug desogestrel. Etonogestrel activates GR signaling and induces FKBP51 mRNA and protein expression in HESCs.

Animal experiment [2]:

Animal models

Female C57BL/6 mice aged 8–12 weeks

Dosage form

Ovariectomized mice received three daily s.c. injections of 100 ng 17β-estradiol. Then mice were rested for 3 days before insertion of one-fourth of a standard Implanon rod containing etonogestrel subcutaneously into the back of the animals. Examine the effect of long-term exposure (up to 45 days) to etonogestrel on endometrium.

Application

Large blood vessels developed in decidualized horns. Disturbance of tissue integrity occurred at 5d with substantial stromal breakdown at 10d. This progress proceeded until 25d when re-epithelialization was initiated. At 45d, the tissue was recovered to its pre-decidualized state but with plentiful tortuosity of the luminal epithelium.

Other notes

Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.

References:

[1]. Kayisli O G, Kayisli U A, Basar M, et al. Progestins Upregulate FKBP51 Expression in Human Endometrial Stromal Cells to Induce Functional Progesterone and Glucocorticoid Withdrawal: Implications for Contraceptive-Associated Abnormal Uterine Bleeding[J]. PloS one, 2015, 10(10): e0137855.

[2]. Morison N B, Zhang J, Tu’uhevaha J, et al. The long-term actions of etonogestrel and levonorgestrel on decidualized and non-decidualized endometrium in a mouse model mimic some effects of progestogen-only contraceptives in women[J]. Reproduction, 2007, 133(1): 309-321.

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Chemical Properties

Cas No. 54048-10-1 SDF Download SDF
Chemical Name (8S,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-17-hydroxy-11-methylene-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
Canonical SMILES CC[[email protected]@]1([[email protected]@]([[email protected]]2([H])CCC3=CC(CC[[email protected]]3([H])[[email protected]@]42[H])=O)([H])CC[[email protected]@]1(O)C#C)CC4=C
Formula C22H28O2 M.Wt 324.46
Solubility >15.1mg/mL in DMSO Storage Store at -20°C
Shipping Condition Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.