DL-AP5
DL-AP5 (CAS 76326-31-3) is a synthetic, water-soluble compound classified as a competitive antagonist, functioning specifically at the N-methyl-D-aspartate (NMDA) receptor in neural tissues and exhibiting antagonist activity at NMDA receptor subtypes in additional neuronal targets. Additionally, it is known to inhibit excitatory neurotransmission mediated by NMDA receptors.
In experimental studies, DL-AP5 blocks NMDA-induced currents with an IC50 value of [ ], tested against isolated neuronal preparations and tissue slices. It can also suppress synaptic transmission by selectively inhibiting NMDA receptor-mediated responses without affecting responses from other glutamate receptor subtypes.
In neuroscience research and electrophysiological applications, DL-AP5 is widely used for studying synaptic plasticity, mapping NMDA receptor functions, and deciphering the roles of NMDA receptors in processes such as long-term potentiation (LTP), neurotoxicity, and synaptic transmission.
| Physical Appearance | A crystalline solid |
| Storage | Store at RT |
| M.Wt | 197.13 |
| Cas No. | 76326-31-3 |
| Formula | C5H12NO5P |
| Synonyms | DL-2-Amino-5-phosphonovaleric acid；2-APV |
| Solubility | insoluble in DMSO; insoluble in EtOH; ≥3.8 mg/mL in H2O |
| Chemical Name | (R)-2-amino-5-phosphonopentanoic acid |
| SDF | Download SDF |
| Canonical SMILES | N[C@H](CCCP(O)(O)=O)C(O)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
