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Digoxin

Catalog No.
B7684
Na+/K+ ATPase pump inhibitor
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$55.00
In stock
100mg
$48.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Digoxin effectively inhibits Na+/K+-ATPase and has the potential to treat arrhythmias and heart failure[1]. 

Digoxin treatment can reduce CHIKV infection of U-2 OS cells, primary human synovial fibroblasts (HSF), and Vero African green monkey kidney cells. Twenty-four hours after treatment with 1 μM digoxin, cell survival is only moderately compromised, which is 20 times the digoxin EC50 dose of the antiviral activity of CHIKV in these cells [1]. 

Reference:

[1]. Ashbrook A W, et al. Antagonism of the Sodium-Potassium ATPase Impairs Chikungunya Virus Infection. MBio, 2016, 7(3): e00693-16.

Chemical Properties

Physical AppearanceA solid
StorageStore at RT
M.Wt780.94
Cas No.20830-75-5
FormulaC41H64O14
Solubility≥33.25mg/mL in DMSO
SDFDownload SDF
Canonical SMILESO[[email protected]]1([[email protected]]([[email protected]@H](C2=CC(OC2)=O)CC1)(C)[[email protected]@H]3O)[[email protected]]4[[email protected]](C3)[[email protected]](CC[[email protected]@H]5O[[email protected]@H](C[[email protected]@H]6O)O[[email protected]](C)[[email protected]]6O[[email protected]@H](C[[email protected]@H]7O)O[[email protected]](C)[[email protected]]7O[[email protected]@H](C[[email protected]@H]8O)O[[email protected]](C)[[email protected]]8O)(C)[[email protected]@H](C5)CC4
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control