Toggle Nav
  • Menu
  • Setting


Catalog No.
Structural analog of PGE2, a selective agonist for the EP2 receptor subtype
Grouped product items
SizePriceStock Qty
500ug (solution)
Ship with 5-10 days
1mg (solution)
Ship with 5-10 days
5mg (solution)
Ship with 5-10 days
10mg (solution)
Ship with 5-10 days

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors


Butaprost, a structural analog of PGE2, is a selective agonist for the EP2 receptor subtype. EP2 receptors are expressed on human neutrophils and on respiratory, vascular, and uterine smooth muscle[1,2]. Butaprost binds with about 1/10 the affinity of PGE2 to the recombinant murine EP2 receptor, and does not bind appreciably to any of the other murine EP receptors or DP, TP, FP, or IP receptors[3]. Butaprost has frequently been used to pharmacologically define the EP receptor expression profile of various human and animal tissues and cells[4]. 


[1]. Regan J W, Bailey T J, Pepperl D J, et al. Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype. Mol. Pharmacol, 1994, 46(2): 213-220.

[2]. Talpain E, Armstrong R A, Coleman R A, et al. Characterization of the PGE receptor subtype mediating inhibition of superoxide production in human neutrophils. British Journal of Pharmacology, 1995, 114(7): 1459-1465.

[3]. Kiriyama M, Ushikubi F, Kobayashi T, et al. Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br. J. Pharmacol, 1997, 122(2): 217-224.

[4]. Lawrence, R.A., and Jones, R.L. Investigation of the prostaglandin E (EP-) receptor subtype mediating relaxation of the rabbit jugular vein. British Journal of Pharmacology, 1992, 105(4): 817-824.

Chemical Properties

Physical AppearanceA solution in acetate. To change the solvent, simply evaporate the acetate containing under a gentle stream of nitrogen and immediately add the solvent of choice.
StorageStore at -20°C
Cas No.69685-22-9
SolubilitySoluble in DMSO
Chemical Namemethyl 7-((1R,2R)-3-hydroxy-2-((S,E)-4-hydroxy-4-(1-propylcyclobutyl)but-1-en-1-yl)-5-oxocyclopentyl)heptanoate
SDFDownload SDF
Canonical SMILESO=C1[[email protected]@H]([[email protected]](C(C1)O)/C=C/C[[email protected]@H](C2(CCC)CCC2)O)CCCCCCC(OC)=O
Shipping ConditionShip with blue ice, or upon other requests.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

View current batch:

Chemical structure