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Apoptosis Inhibitor Associate with caspase-3 inhibition

Catalog No.A1930
Size Price Stock Qty
10mM (in 1mL DMSO)
$50.00
In stock
Evaluation Sample
$28.00
In stock
10mg
$80.00
In stock
25mg
$160.00
In stock
100mg
$350.00
In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

Apoptosis Inhibitor

Biological Activity

Description Apoptosis Inhibitor is a cell-permeable inhibitor of apoptosis induction.
Targets Caspase          
IC50            

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Chemical Properties

Cas No. 54135-60-3 SDF Download SDF
Chemical Name 2-[(2,6-dioxocyclohexyl)methyl]cyclohexane-1,3-dione
Canonical SMILES C1CC(=O)C(C(=O)C1)CC2C(=O)CCCC2=O
Formula C13H16O4 M.Wt 236.3
Solubility >9.1mg/mL in DMSO Storage Store at 4°C
Shipping Condition Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Background

M50054, 2,2'-methylenebis (1,3-cyclohexanedione), is a novel inhibitor of apoptosis. [1]

In human Fas-expressing WC8 cells, M50054 inhibited apoptosis by soluble human Fas ligand in vitro cell death assay. M50054 inhibited the apoptotic U937 cell death which is a human monocytic leukemic cell line, induced by anticancer agents such as etoposide. M50054 inhibited apoptotic characters such as DNA phosphatidylserine and fragmentation exposure in these cells. These anti-apoptotic effects were dependent on inhibition of caspase-3 activation. Additionally, M50054 significantly inhibited anti-Fas-antibody-induced elevation of plasma aspartate aminotransferase and alanine aminotransferase. Alopecia (hair loss) symptoms were also significantly improved with topical treatment with M50054. M50054 inhibits apoptosis induced by a variety of stimuli via inhibition of caspase-3 activation, and may thus be effective for hepatitis and chemotherapy-induced alopecia. [1]

Reference:
Tsuda T, Ohmori Y, Muramatsu H et al.  Inhibitory effect of M50054, a novel inhibitor of apoptosis, on anti-Fas-antibody-induced hepatitis and chemotherapy-induced alopecia.Eur J Pharmacol. 2001 Dec 14;433(1):37-45.