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Angiotensin 1/2 (1-7) amide

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Angiotensin I/II (1-7) amide (H2N-Asp-Arg-Val-Tyr-Ile-His-Pro-amide) is a peptide analog to angiotensin II that is used as a vasopressor in the treatment of certain types of shock and circulatory collapse.

Angiotensin II (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe | His-Leu) is an octapeptide that is converted from Angiotensin I (AI) through the removal of two C-terminal residues by angiotensin-converting enzyme (ACE), primarily by ACE within the lung (but also those present in endothelial and kidney epithelial cells). Ang-(1–7) is an endogenous peptide fragment that can be produced from Ang I or Ang II via endo- or carboxy-peptidases respectively. [1]

Angiotensin I/II (1-7) amide is an amide derivative of angiotensin II that is a powerful vasoconstrictor and vasopressor, and is used in the treatment of certain hypotensive states. Angiotensin I/II (1-7) amide is usually administered by slow intravenous infusion, and sometimes intramuscularly or subcutaneously.

 Fig. 1: Formula of Angiotensin I/II (1-7) amide


1. Santos et al (2000) Angiotensin-(1-7): an update. Regul.Pept. 91 45.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
Solubility≥89.8mg/mL in DMSO
SDFDownload SDF
Canonical SMILESO=C(N)[[email protected]@H]1N(C([[email protected]@H](NC([[email protected]@H](NC([[email protected]@H](NC([[email protected]@H](NC([[email protected]@H](NC(CNC)=O)CCCNC(N)=N)=O)C)=O)CC2=CC=C(O)C=C2)=O)[[email protected]@H](C)CC)=O)CC3=CNC=N3)=O)CCC1
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

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Chemical structure

Angiotensin 1/2 (1-7) amide