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4-HQN

In stock
Catalog No.
A4524
PARP inhibitor
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$60.00
In stock
50mg
$85.00
In stock

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Inhibitor of poly(ADP-ribose) polymerase (PARP) (IC50 = 9.5 μM); displays mixed inhibition with respect to NAD+. Protective against ischemia-reperfusion induced ROS production, and subsequent mitochondrial and cell damage in rat heart. Anti-inflammatory in LPS-induced endotoxic mice in vivo; decreases NF-κB and AP-1 activation.

Chemical Properties

Physical AppearanceA solid
StorageDesiccate at RT
M.Wt146.15
Cas No.491-36-1
FormulaC8H6N2O
Solubility≥55.6mg/mL in DMSO, ≥4.55 mg/mL in EtOH with ultrasonic and warming, <2.52 mg/mL in H2O
Chemical Name1H-quinazolin-4-one
SDFDownload SDF
Canonical SMILESC1=CC=C2C(=C1)C(=O)N=CN2
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Quality Control

Chemical structure

4-HQN