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4-HQNPARP inhibitor

4-HQN

Catalog No. A4524
Size Price Stock Qty
10mM (in 1mL DMSO) $60.00 In stock
50mg $85.00 In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

4-HQN

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Chemical Properties

Cas No. 491-36-1 SDF Download SDF
Chemical Name 1H-quinazolin-4-one
Canonical SMILES C1=CC=C2C(=C1)C(=O)N=CN2
Formula C8H6N2O M.Wt 146.15
Solubility >55.6mg/mL in DMSO Storage Desiccate at RT
General tips N/A
Shipping Condition N/A

Background

Inhibitor of poly(ADP-ribose) polymerase (PARP) (IC50 = 9.5 μM); displays mixed inhibition with respect to NAD+. Protective against ischemia-reperfusion induced ROS production, and subsequent mitochondrial and cell damage in rat heart. Anti-inflammatory in LPS-induced endotoxic mice in vivo; decreases NF-κB and AP-1 activation.