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3-Bromopyruvic acid

Catalog No.
B7922
HB7922exokinase II inhibitor
Grouped product items
SizePriceStock Qty
1g
$50.00
In stock
5g
$60.00
In stock
10g
$80.00
In stock
25g
$160.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

3-Bromopyruvic acid (3-BP) is a hexokinase II inhibitor with Ki of 2.4 mM, is an effective antitumor agent on the hepatoma cells[1]. 

3-BP decreases proliferation of hepatocellular carcinoma BEL-7402 cells that express hexokinase II, an isoform of hexokinase overexpressed in many cancers[2,3]. 

3-BP reduces tumor growth and induces tumor necrosis in a hepatocellular carcinoma mouse xenograft model when administered at a dose of 50 mg/kg per day, six days per week, for three weeks[2]. 

References:

[1]. Ihrlund L S, Hernlund E, Khan O, et al. 3-Bromopyruvate as inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs. Molecular Oncology, 2008, 2(1): 94-101.

[2]. Gong L, Wei Y, Yu X, et al. 3-Bromopyruvic acid, a hexokinase II inhibitor, is an effective antitumor agent on the hepatoma cells: In vitro and in vivo findings. Anticancer Agents Med. Chem, 2014, 14(5): 771-776.

[3]. Lis P, Dylag M, Niedźwiecka K, et al. The HK2 dependent "Warburg Effect" and mitochondrial oxidative phosphorylation in cancer: Targets for effective therapy with 3-bromopyruvate. Molecules, 2016, 21(12): E1730.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt166.96
Cas No.1113-59-3
FormulaC3H3BrO3
SynonymsBromopyruvic acid; Hexokinase II Inhibitor II, 3-BP
Solubility≥16.7mg/mL in H2O
Chemical Name3-bromo-2-oxopropanoic acid
SDFDownload SDF
Canonical SMILESBrCC(C(O)=O)=O
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

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