3-Bromopyruvic acid
Catalog No.
B7922
HB7922exokinase II inhibitor
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3-Bromopyruvic acid (CAS 1113-59-3), abbreviated as 3-BP, is a small molecule inhibitor that targets hexokinase II (HK2), an enzyme notably upregulated in cancerous cells. By inhibiting HK2 activity (Ki = 2.4 mM), 3-BP interferes with glycolytic energy metabolism, leading to reduced tumor cell proliferation in hepatocellular carcinoma BEL-7402 cells. In mouse xenograft models of hepatocellular carcinoma, administration of 3-BP (50 mg/kg/day, six days weekly for three weeks) results in decreased tumor growth and increased tumor necrosis. This compound serves as a tool in oncology research, particularly for studying glycolysis-dependent tumor metabolism.
- 1. Theresa K Leslie, Aurelien Tripp, et al. "A novel Nav1.5-dependent feedback mechanism driving glycolytic acidification in breast cancer metastasis." Oncogene. 2024 Aug;43(34):2578-2594 PMID: 39048659
- 2. Michaela T. Reichmann, Liku B Tezera, et al. "Integrated transcriptomic analysis of human tuberculosis granulomas and a biomimetic model identifies therapeutic targets." J Clin Invest. 2021 Aug 2;131(15):e148136. PMID: 34128839
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 166.96 |
| Cas No. | 1113-59-3 |
| Formula | C3H3BrO3 |
| Synonyms | Bromopyruvic acid; Hexokinase II Inhibitor II, 3-BP |
| Solubility | ≥16.7 mg/mL in H2O; ≥23.55 mg/mL in DMSO; ≥49.5 mg/mL in EtOH |
| Chemical Name | 3-bromo-2-oxopropanoic acid |
| SDF | Download SDF |
| Canonical SMILES | OC(C(CBr)=O)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
