In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
3-Bromopyruvic acid (3-BP) is a hexokinase II inhibitor with Ki of 2.4 mM, is an effective antitumor agent on the hepatoma cells.
3-BP decreases proliferation of hepatocellular carcinoma BEL-7402 cells that express hexokinase II, an isoform of hexokinase overexpressed in many cancers[2,3].
3-BP reduces tumor growth and induces tumor necrosis in a hepatocellular carcinoma mouse xenograft model when administered at a dose of 50 mg/kg per day, six days per week, for three weeks.
. Ihrlund L S, Hernlund E, Khan O, et al. 3-Bromopyruvate as inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs. Molecular Oncology, 2008, 2(1): 94-101.
. Gong L, Wei Y, Yu X, et al. 3-Bromopyruvic acid, a hexokinase II inhibitor, is an effective antitumor agent on the hepatoma cells: In vitro and in vivo findings. Anticancer Agents Med. Chem, 2014, 14(5): 771-776.
. Lis P, Dylag M, Niedźwiecka K, et al. The HK2 dependent "Warburg Effect" and mitochondrial oxidative phosphorylation in cancer: Targets for effective therapy with 3-bromopyruvate. Molecules, 2016, 21(12): E1730.
|Physical Appearance||A solid|
|Storage||Store at -20°C|
|Synonyms||Bromopyruvic acid; Hexokinase II Inhibitor II, 3-BP|
|Solubility||≥16.7mg/mL in H2O|
|Chemical Name||3-bromo-2-oxopropanoic acid|
|Shipping Condition||Evaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.|
|General tips||For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.|
Quality Control & MSDS
- View current batch:
Purity = 98.00%
- COA (Certificate Of Analysis)
- NMR (Nuclear Magnetic Resonance)
- MSDS (Material Safety Data Sheet)