1,2,3,4,5,6-Hexabromocyclohexane|JAK2 tyrosine kinase inhibitor|CAS# 1837-91-8

Size	Price	Stock	Qty
10mM (in 1mL DMSO)	$50.00	In stock
50mg	$106.00	In stock

Publications citing ApexBio Products

Nature.
2017 Jan 19;541(7637):417-420.

Nature.
2018 Mar 29;555(7698):673-677.

Nature.
2016 Apr 21;532(7599):398-401.

Science.
2016 Aug 5;353(6299)594-8

Nature Biotechnology.
2017 Jun;35(6):569-576

Cell.
2018 Feb 22;172(5):1007-1021.e17.

Cell.
2017 Nov 30;171(6):1284-1300.e21.

Cell.
2017 Aug 17. pii: S0092-8674(17)30869-3.

Cell.
2017 Jul 13;170(2):312-323

Nat Med.
2018 Jan 29.

Cell.
2017 Apr 6;169(2):286-300.

Cell.
2015 Aug 27;162(5):987-1002.

Cell.
2015 Feb 12;160(4):729-44.

Nature Medicine.
2017 Apr;23(4):493-500.

Cancer Cell.
2018 Mar 12;33(3):401-416.e8.

Cancer Cell.
2017 Aug 14;32(2):253-267.e5.

Cell Stem Cell.
2017 Nov 20. pii: S1934-5909(17)30375-2.

Cancer Cell.
2017 May 8;31(5):635-652.e6.

Immunity.
2018 Jan 16;48(1):59-74.e5.

Immunity.
2017 Oct 17;47(4):635-647.e6.

Immunity.
2016 Jan 19;44(1):88-102

Nat Cell Biol.
2018 Feb;20(2):186-197.

Nat Cell Biol.
2017 Dec 11.

Nat Cell Biol.
2015 May;17(5):627-38.

Nat Immunol.
2017 Jun;18(6):654-664.

Sci Transl Med.
2017 Dec 13;9(420). pii: eaal3765.

Sci Transl Med.
2017 Nov 22;9(417). pii: eaan8462.

Nat Neurosci.
2015 Oct;18(10):1464-73.

Cell Host Microbe.
2017 Oct 11;22(4):561-573.e4.

Cell Res.
2016 Sep;26(9):1007-20.

Mol Cell.
2017 Nov 16;68(4):731-744.e9.

Mol Cell.
2017 Oct 5;68(1):210-223.e6.

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Quality Control

Quality Control & MSDS

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Purity = 98.00%

Chemical structure

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Chemical Properties

Cas No.	1837-91-8	SDF	Download SDF
Chemical Name	1,2,3,4,5,6-hexabromocyclohexane
Canonical SMILES	C1(C(C(C(C(C1Br)Br)Br)Br)Br)Br
Formula	C₆H₆Br₆	M.Wt	557.54
Solubility	>8.21mg/mL in DMSO	Storage	Store at RT
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

Background

Potently and directly inhibits JAK2 tyrosine kinase autophosphorylation, specifically inhibiting ligand-dependent JAK2 activation. A 16-hour treatment with 1 μM of compound reduces JAK2 tyrosine autophosphorylation levels to ~ 50% while 50 μM elimates nearly all JAK2 activity. Non-cytotoxic at 100 μM.