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WIKI4

In stock
Catalog No.
A4531
Inhibitor of Wnt/ß-Catenin signaling and tankyrase
Grouped product items
SizePriceStock Qty
10mg
$193.00
In stock
50mg
$793.00
In stock

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Inhibitor of Wnt/β-catenin signaling (EC50 ~ 75 nM). Inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) (IC50 ~15 nM); prevents the ubiquitination and degradation of axin.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt521.59
Cas No.838818-26-1
FormulaC29H23N5O3S
Solubility≥26.1mg/mL in DMSO with gentle warming
Chemical Name2-(3-((4-(4-methoxyphenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)propyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione
SDFDownload SDF
Canonical SMILESO=C1N(CCCSC2=NN=C(C3=CC=NC=C3)N2C4=CC=C(OC)C=C4)C(C5=CC=CC6=CC=CC1=C56)=O
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Biological Activity

Description WIKI4 is a novel inhibitor of Tankyrase with IC50 value of 15 nM for TNKS2.
Targets TNKS2          
IC50 15 nM          

Quality Control

Chemical structure

WIKI4