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WIKI4Inhibitor of Wnt/ß-Catenin signaling and tankyrase

WIKI4

Catalog No. A4531
Size Price Stock Qty
10mM (in 1mL DMSO) $160.00 In stock
10mg $193.00 In stock
50mg $793.00 In stock

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Sample solution is provided at 25 µL, 10mM.

Quality Control

Quality Control & MSDS

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Chemical structure

WIKI4

Biological Activity

Description WIKI4 is a novel inhibitor of Tankyrase with IC50 value of 15 nM for TNKS2.
Targets TNKS2          
IC50 15 nM          

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Chemical Properties

Cas No. 838818-26-1 SDF Download SDF
Chemical Name 2-(3-((4-(4-methoxyphenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)propyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione
Canonical SMILES O=C1N(CCCSC2=NN=C(C3=CC=NC=C3)N2C4=CC=C(OC)C=C4)C(C5=CC=CC6=CC=CC1=C56)=O
Formula C29H23N5O3S M.Wt 521.59
Solubility Soluble in DMSO > 10 mM Storage Store at -20°C
General tips N/A
Shipping Condition N/A

Background

Inhibitor of Wnt/β-catenin signaling (EC50 ~ 75 nM). Inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) (IC50 ~15 nM); prevents the ubiquitination and degradation of axin.