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6-Hydroxydopamine hydrobromide

Catalog No.
B7099
neurotoxin that destroys dopaminergic and noradrenergic (catecholaminergic) neurons
Grouped product items
SizePriceStock Qty
50mg
$53.00
In stock

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Email: [email protected]

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Background

6-Hydroxydopamine hydrobromide (6-OHDA hydrobromide) is a catecholaminergic neurotoxin that has been used to induce dopaminergic lesions and parkinsonian symptoms as a model of Parkinson's disease in rodents[1]. 

6-OHDA hydrobromide (75 μM) activates caspase-3, -8, and -9 in a time-dependent manner and increases the level of intracellular reactive oxygen species (ROS) in PC12 cells and induces apoptosis in rat substantia nigra when stereotaxically injected into the right MFB[2]. 

6-OHDA hydrobromide induces locomotor impairment in mice and loss of tyrosine hydroxylase-reactive neurons in mouse brain when administered into the substantia nigra, medial forebrain bundle (MFB), or striatum at doses of 9, 6, and 18 μg, respectively[3]. 

References:

[1]. Blum D, Torch S, Lambeng N, et al. Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: Contribution to the apoptotic theory in Parkinson’s disease. Prog. Neurobiol, 2001, 65(2): 135-172.

[2]. Fujita H, Ogino T, Kobuchi H, et al. Cell-permeable cAMP analog suppresses 6-hydroxydopamine-induced apoptosis in PC12 cells through the activation of the Akt pathway. Brain Res, 2006, 1113(1): 10-23.

[3]. Heuer A, Smith G A, Lelos M J, et al. Unilateral nigrostriatal 6-hydroxydopamine lesions in mice I: Motor impairments identify extent of dopamine depletion at three different lesion sites. Behav. Brain Res, 2012, 228(1): 30-43.

Chemical Properties

StorageDesiccate at -20°C
M.Wt250.09
Cas No.636-00-0
FormulaC8H11NO3·HBr
Solubility≥25mg/mL in DMSO with ultrasonic
Chemical Name5-(2-aminoethyl)benzene-1,2,4-triol hydrobromide
SDFDownload SDF
Canonical SMILESOC(C(CCN)=C1)=CC(O)=C1O.Br
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

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