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Proteases

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for  Proteases

product-structure
  1. Cat.No. Product Name Information
  2. C3609 (Z-Ala-Ala-Ala-Ala)2Rh110 fluorogenic elastase substrate
  3. A4054 17-AAG (KOS953) Hsp90 inhibitor
  4. A2213 17-DMAG (Alvespimycin) HCl Hsp90 inhibitor
  5. C5038 2-cyano-Pyrimidine cathepsin K inhibitor
  6. C3265 2-Guanidinoethylmercaptosuccinic Acid carboxypeptidase E inhibitor
  7. B7734 2-MPPA glutamate carboxypeptidase II (GCP II) inhibitor
  8. A4445 4-Chlorophenylguanidine hydrochloride Urokinase inhibitor, potent and specific
  9. A3126 5-R-Rivaroxaban Factor Xa (FXa) inhibitor
  10. A4418 Ac-IEPD-AFC Recognition motif for serine protease granzyme B
  11. A4419 Ac-LEHD-AFC Fluorogenic caspase substrate

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