In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
p-Chlorophenylalanine is a selective irreversible inhibitor of tryptophan hydroxylase. Tryptophan hydroxylase is the rate-limiting enzyme in the synthesis of serotonin (5-hydroxytryptamine). p-Chlorophenylalanine can deplete endogenous serotonin levels.
p-Chlorophenylalanine significantly attenuates pulmonary vascular remodeling and lung inflammation induced by MCT (Wild Lily), inhibits Tph-1 and SERT, MMP-2/ -9, TIMP-1/-2. Expression of IL-1β, TNF-α, ICAM-1. p-Chlorophenylalanine inhibits 5-HT by inhibiting Tph-1, regulating SERT and serotonin downstream signaling pathways.
. Bai Y, Wang H, Liu M, et al. 4-Chloro-DL-phenylalanine protects against monocrotaline‑induced pulmonary vascular remodeling and lung inflammation. International Journal of Molecular Medicine, 2014, 33(2): 373-382.
|Physical Appearance||A solid|
|Storage||Store at RT|
|Solubility||insoluble in EtOH; insoluble in DMSO; ≥4.58 mg/mL in H2O with gentle warming and ultrasonic|
|Chemical Name||(R)-2-amino-3-(4-chlorophenyl)propanoic acid|
|Canonical SMILES||ClC1=CC=C(C=C1)C[[email protected]](C(O)=O)N|
|Shipping Condition||Evaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.|
|General tips||For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.|