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Catalog No.
compound used to bind irreversibly to tryptophan hydroxylase
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p-Chlorophenylalanine is a selective irreversible inhibitor of tryptophan hydroxylase. Tryptophan hydroxylase is the rate-limiting enzyme in the synthesis of serotonin (5-hydroxytryptamine). p-Chlorophenylalanine can deplete endogenous serotonin levels. 

p-Chlorophenylalanine significantly attenuates pulmonary vascular remodeling and lung inflammation induced by MCT (Wild Lily), inhibits Tph-1 and SERT, MMP-2/ -9, TIMP-1/-2. Expression of IL-1β, TNF-α, ICAM-1. p-Chlorophenylalanine inhibits 5-HT by inhibiting Tph-1, regulating SERT and serotonin downstream signaling pathways. 


[1]. Bai Y, Wang H, Liu M, et al. 4-Chloro-DL-phenylalanine protects against monocrotaline‑induced pulmonary vascular remodeling and lung inflammation. International Journal of Molecular Medicine, 2014, 33(2): 373-382.

Chemical Properties

Physical AppearanceA solid
StorageStore at RT
Cas No.7424-00-2
Solubilityinsoluble in EtOH; insoluble in DMSO; ≥4.58 mg/mL in H2O with gentle warming and ultrasonic
Chemical Name(R)-2-amino-3-(4-chlorophenyl)propanoic acid
SDFDownload SDF
Canonical SMILESClC1=CC=C(C=C1)C[[email protected]](C(O)=O)N
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

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