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NVP 231

Catalog No.
B1235
CerK inhibitor
Grouped product items
SizePriceStock Qty
10mg
$43.00
In stock
25mg
$90.00
In stock
50mg
$169.00
In stock
100mg
$304.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

NVP 231 is a potent, reversible and specific inhibitor of ceramide kinase(CerK) with the IC50 value of 12±2nM in radio assay [1].

NVP 231 has been noted to inhibit CerK with the IC50 value of 12±2nM and have the 90% inhibition at 100 nM in the radio assay. In addition, NVP 231 has been reported to compete with ceramide with the Ki value of 7.4 nM. Furthermore, NVP 231 has been revealed to achieve complete inhibition of CIP at 100nM. NVP 231 in an assay based on human CerK-overexpressing COS-cells (COS-CerK). And the study has been exhibited that NVP 231 is a more potent inhibitor of mouse CerK. Apart from these, NVP 231 has been shown the specificity to CerK with the IC50 values of 0.01 μM, 100 μM, >100 μM, 5 μM, >25 μM, >25 μM, >10 μM, >10 μM and >10 μM for hCerK, hSphK1, hSphK2, hDAGKα, hPI3Kα, hVps34, hGCS, hSMS-1 and CERT, respectively [1].

References:
[1]Graf C1, Klumpp M, Habig M, Rovina P, Billich A, Baumruker T, Oberhauser B, Bornancin F. Targeting ceramide metabolism with a potent and specific ceramide kinase inhibitor. Mol Pharmacol. 2008 Oct;74(4):925-32.

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Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt431.55
Cas No.362003-83-6
FormulaC25H25N3O2S
Solubilityinsoluble in H2O; ≥2.58 mg/mL in EtOH with gentle warming and ultrasonic; ≥87.6 mg/mL in DMSO with ultrasonic
Chemical NameN-(2-benzamido-1,3-benzothiazol-6-yl)adamantane-1-carboxamide
SDFDownload SDF
Canonical SMILESC1C2CC3CC1CC(C2)(C3)C(=O)NC4=CC5=C(C=C4)N=C(S5)NC(=O)C6=CC=CC=C6
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

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