N1-Methylguanosine-5'-Triphosphate
Catalog No.
B7991
Modified nucleoside triphosphate with methylation at the N1 position of guanine, affecting RNA translation and stability.
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N1-Methylguanosine-5'-Triphosphate (N1-meGTP) is a modified nucleoside triphosphate in which the N1 position of guanine is methylated. This modification can significantly influence RNA structure, stability, and translation. N1-meGTP can be incorporated into RNA molecules during in vitro transcription reactions, generating RNA containing N1-methylguanosine. The modification may interfere with RNA interactions with nucleic acid-binding proteins, affecting RNA's secondary structure and function. N1-meGTP is frequently used to study the role of RNA methylation in gene expression regulation, particularly in mRNA translation initiation and control. Additionally, abnormal RNA methylation has been implicated in numerous viral infections and cancers, suggesting potential applications for N1-meGTP in developing antiviral drugs and anticancer therapies.
| Physical Appearance | Solution |
| Storage | Store at -20°C or below |
| M.Wt | 537.21 (free acid) |
| Formula | C11H18N5O14P3 (free acid) |
| Synonyms | N1-Methyl-GTP |
| Chemical Name | lithium (5-(2-amino-1-methyl-6-oxo-1H-purin-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl triphosphate |
| SDF | Download SDF |
| Canonical SMILES | O=C1N(C)C(N)=NC2=C1N=CN2C3C(O)C(O)C(COP([O-])(OP([O-])(OP([O-])([O-])=O)=O)=O)O3.[Li+].[Li+].[Li+].[Li+] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Purity = ≥90% by AX-HPLC
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
