2'-O-Methyl-2-Amino-ATP
Catalog No.
B7992
Modified nucleoside triphosphate with methylation at the 2'-hydroxyl group and an amino substitution at the 2-position of the adenine ring, used for RNA stability studies.
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2'-O-Methyl-2-Amino-ATP is a modified nucleoside triphosphate wherein the 2'-hydroxyl group on adenosine is methylated, and the adenine ring carries an amino substitution at the 2-position. This dual modification significantly alters the nucleotide's chemical properties and biological functionalities. 2'-O-Methyl-2-Amino-ATP can be incorporated into RNA molecules during in vitro transcription reactions, producing RNAs containing this modification. The methylation enhances RNA stability by reducing susceptibility to exonuclease degradation, facilitating the study of RNA functions in both in vitro and in vivo experiments. Furthermore, the amino modification can influence RNA secondary structure and its interactions with proteins, making it particularly valuable for studying RNA-protein interactions as well as RNA modifications and functions.
| Physical Appearance | Solution |
| Storage | Store at -20°C or below |
| M.Wt | 536.2 (free acid) |
| Formula | C11H19N6O13P3 (free acid) |
| Synonyms | 2'-O-Methyl-2-aminoadenosine-5'-Triphosphate, 2'-O-Methyl-2,6-Diaminopurine-ribose-5'-Triphosphate, 2'-O-Methyl-DAP-rTP |
| Chemical Name | lithium (5-(2,6-diamino-9H-purin-9-yl)-3-hydroxy-4-methoxytetrahydrofuran-2-yl)methyl triphosphate |
| SDF | Download SDF |
| Canonical SMILES | NC1=NC(N)=NC2=C1N=CN2C3C(OC)C(O)C(COP([O-])(OP([O-])(OP([O-])([O-])=O)=O)=O)O3.[Li+].[Li+].[Li+].[Li+] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Purity = ≥90% by AX-HPLC
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
