Applications
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In the normal human mammary epithelial cell line 184, TTNPB inhibited cell growth. In T47D cells, TTNPB arrested the cell cycle in the G0/G1 phase and induced apoptosis. Further study showed that TTNPB induced cell cycle blockade mainly by suppressing Cyclin D1 and Cyclin D3 protein activity. But TTNPB did not change the expression of Cyclin D1 protein in a biologically relevant manner.
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Applications
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In both MXT-HS and MXT-HI models, TTNPB exhibited equal inhibition on tumor growth. Comparing with Tamoxifen, TTNPB was markedly more efficient in inhibiting cell proliferation and triggering apoptosis. TTNPB inhibited MXT-HS growth rate by inducing apoptosis rather than inhibiting cell proliferation.
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References:
[1]. Wu K, DuPré E, Kim H, Tin-U CK, Bissonnette RP, Lamph WW, Brown PH. Receptor-selective retinoids inhibit the growth of normal and malignant breast cells by inducing G1 cell cycle blockade. Breast Cancer Res Treat. 2006 Mar;96(2):147-57.
[2]. Darro F, Cahen P, Vianna A, Decaestecker C, Nogaret JM, Leblond B, Chaboteaux C, Ramos C, Pétein M, Budel V, Schoofs A, Pourrias B, Kiss R. Growth inhibition of human in vitro and mouse in vitro and in vivo mammary tumor models by retinoids in comparison with tamoxifen and the RU-486 anti-progestagen. Breast Cancer Res Treat. 1998 Sep;51(1):39-55.
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