Biotin-11-dCTP
Catalog No.
B8346
Biotin-labeled nucleotide analogues used to form biotin-labeled DNA
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Biotin-11-dCTP (CAS 136632-30-9) is a biotinylated nucleotide analog designed for incorporation into DNA or cDNA in enzymatic reactions such as PCR and nick translation. It substitutes natural dCTP through polymerase-mediated incorporation. The biotin moiety, linked via an 11-atom spacer at cytidine's C5 position, facilitates subsequent detection utilizing streptavidin-conjugated molecules (e.g., horseradish peroxidase, alkaline phosphatase, fluorescent dyes, or affinity beads). Biotin-11-dCTP serves as an essential reagent to produce detectable nucleic acid probes, commonly applied in molecular hybridization assays and genomic studies.
- 1. Yongfeng Zhou, Hao Yu, et al. "Imprinted lncRNA KCNQ1OT1 regulates CDKN1C expression through promoter binding and chromatin folding in pigs." Gene. 2024 Sep 25:923:148590. PMID: 38772516
- 2. Yao Liu, Xiao Chen, et al. "Small cytosolic double-stranded DNA represses cyclic GMP-AMP synthase activation and induces autophagy." Cell Rep. 2023 Aug 29;42(8):112852. PMID: 37481718
| Physical Appearance | Solution |
| Storage | Store at -20°C or below |
| M.Wt | 859.67 (free acid) |
| Cas No. | 136632-30-9 |
| Formula | C28H44N7O16P3S (free acid) |
| Synonyms | Biotin-X-5-Propargylamino-dCTP |
| Chemical Name | γ-[N-(Biotin-6-amino-hexanoyl)]-5-propargylamino-2'-deoxycytidine-5'-triphosphate, Triethylammonium salt |
| SDF | Download SDF |
| Canonical SMILES | O=C1N([C@@H]2O[C@H](COP(OP(OP(O)(O)=O)(O)=O)(O)=O)[C@@H](O)C2)C=C(C#CCNC(CCCCCNC(CCCC[C@@]3([H])[C@](NC(N4)=O)([H])[C@]4([H])CS3)=O)=O)C(N)=N1 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
