SM-102
Catalog No.
C1042
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SM-102 is an ionizable cationic lipid that serves as a cornerstone component in Lipid Nanoparticle (LNP) systems for the delivery of mRNA vaccines and gene therapies.
● Key Function: It remains neutral at physiological pH to minimize toxicity, but becomes positively charged in the acidic environment of the endosome. This allows for efficient encapsulation of negatively charged mRNA and facilitates its intracellular release.
● Applications: Widely used in the development of prophylactic vaccines (e.g., COVID-19 mRNA vaccines), cancer immunotherapy, and gene-editing therapeutics.
● Advantages: Features high transfection efficiency, excellent biodegradability, and a proven clinical safety profile.
- 1. Haizong Fang, Peidong You, et al. "Annexin A1 mRNA-loaded liposomes alleviate acute pancreatitis by suppressing STING pathway and promoting efferocytosis in macrophages." Nat. Nanotechnol. (2025).
- 2. Zhijie Lian, Lingying Zheng, et al. "Breaking Endosomal Barriers: Thiol-Mediated Uptake Lipid Nanoparticles for Efficient mRNA Vaccine Delivery." J Am Chem Soc. 2025 Jul 22 PMID: 40694665
- 3. Yuang Gu, Jingqu Chen, et al. "mRNA delivery enabled by metal–organic nanoparticles." Nat Commun. 2024 Nov 8;15(1):9664 PMID: 39511206
- 4. Wei Wang, Shuo Feng, et al. "Prediction of lipid nanoparticles for mRNA vaccines by the machine learning algorithm." Acta Pharm Sin B.
| Storage | Store at -20°C or below |
| M.Wt | 710.18 |
| Cas No. | 2089251-47-6 |
| Formula | C44H87NO5 |
| Solubility | insoluble in DMSO; ≥175.8 mg/mL in EtOH; insoluble in H2O |
| Chemical Name | heptadecan-9-yl 8-((2-hydroxyethyl)(6-oxo-6-(undecyloxy)hexyl)amino)octanoate |
| SDF | Download SDF |
| Canonical SMILES | CCCCCCCCC(CCCCCCCC)OC(CCCCCCCN(CCO)CCCCCC(OCCCCCCCCCCC)=O)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
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