D-Lin-MC3-DMA
siRNA-based drugs need a complicated delivery vehicle, that’s because it degraded rapidly in the circulation, difficult to cross the cell membranes and enter the cytoplasm, plus inefficient accumulation in target tissues. The major delivery technology for siRNA is the lipid nanoparticle (LNP) containing ionizable amino lipid, which is the consisted of an ionizable amino lipid (heptatriaconta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate, DLin-MC3-DMA), a phosphatidylcholine (1,2-distearoyl-sn-glycero-3-phosphocholine, DSPC), cholesterol and a coat lipid (polyethylene glycol-dimyristolglycerol, PEG-DMG). As a potent siRNA delivery vehicle, DLin-MC3-DMA is 1000-fold more potent for silencing of a hepatic gene (Factor VII), comparing to its precursor lipid DLin-DMA. The ED50 for LNP containing DLin-MC3-DMA to silence Factor VII was 0.005 mg/kg for mice, and 0.03 mg/kg for TTR in non-human primates.
Reference:
Tam YY, Chen S, Cullis PR. Advances in Lipid Nanoparticles for siRNA Delivery. Pharmaceutics. 2013 Sep 18;5(3):498-507. PMID: 24300520.
- 1. Tianchuan Zhu , Zhenxing Chen, et al. "Sequential Targeting Hybrid Nanovesicles Composed of Chimeric Antigen Receptor T-Cell-Derived Exosomes and Liposomes for Enhanced Cancer Immunochemotherapy." ACS Nano. 2023 Aug 25. PMID: 37624742
- 2. Wei Wang, Shuo Feng, et al. "Prediction of lipid nanoparticles for mRNA vaccines by the machine learning algorithm." Acta Pharm Sin B.
| Storage | Store at -20°C or below |
| M.Wt | 642.09 |
| Cas No. | 1224606-06-7 |
| Formula | C43H79NO2 |
| Synonyms | Dlin-MC3-DMA; DLin |
| Solubility | insoluble in H2O; insoluble in DMSO; ≥152.6 mg/mL in EtOH |
| Chemical Name | (6Z,9Z,28Z,31Z)-heptatriaconta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate |
| SDF | Download SDF |
| Canonical SMILES | O=C(CCCN(C)C)OC(CCCCCCCC/C=C\C/C=C\CCCCC)CCCCCCCC/C=C\C/C=C\CCCCC |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
