Schizandrin B
Catalog No.
N1656
inhibits lipid peroxidation
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Schizandrin B (CAS: 61281-37-6) is a dibenzocyclooctadiene lignan isolated from Schisandra fruit. It exhibits antioxidant activity by scavenging hydroxyl and superoxide radicals, inhibiting lipid peroxidation in vitro through NADPH/ascorbate and cysteine/iron systems. In mouse models of doxorubicin-induced cardiotoxicity, Schizandrin B reduces cardiac lipid peroxidation, protein nitration, metalloprotease activation, cardiomyocyte apoptosis, DNA damage, and inflammation via suppression of MAPK-p38 phosphorylation and p53 activation. These properties make Schizandrin B valuable for investigating oxidative stress-related cardiovascular injury.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 400.46 |
| Cas No. | 61281-37-6 |
| Formula | C23H28O6 |
| Solubility | insoluble in EtOH; insoluble in H2O; ≥20 mg/mL in DMSO |
| Chemical Name | 1,2,3,13-tetramethoxy-6,7-dimethyl-5,6,7,8-tetrahydrobenzo[3',4']cycloocta[1',2':4,5]benzo[1,2-d][1,3]dioxole |
| SDF | Download SDF |
| Canonical SMILES | C[C@@H](Cc(cc1OCOc1c1OC)c1-c1c2OC)[C@H](C)Cc1cc(OC)c2OC |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
