TNP-ATP triethylammonium salt
Catalog No.
B7066
P2X receptor antagonist
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TNP-ATP triethylammonium salt (CAS 61368-63-6) is a selective antagonist of purinergic P2X receptors, functioning by inhibiting P2X receptor-mediated ion channel activity. Through blockade of these receptor subtypes, TNP-ATP triethylammonium modulates neuronal excitability and pain signal transduction. Experimental evidence from animal pain models demonstrates that administration of this compound reduces nociceptive sensitivity, highlighting its utility as a research tool for studying the relationship between purinergic signaling pathways and pain modulation mechanisms, particularly within neurobiological contexts.
- 1. Yueling Zhu, Shiyan Lin, et al. "ATP promotes protein coacervation through conformational compaction." J Mol Cell Biol. 2024 Oct 1:mjae038. PMID: 39354680
- 2. Zhou Gong, Yueling Zhu, et al. "Conformational compaction as a mechanism for ATP resolubilization of protein condensates." Research Square. 26 Jun, 2023
| Physical Appearance | A 10 mM solution in water |
| Storage | Desiccate at -20°C |
| M.Wt | 1123.04 |
| Cas No. | 61368-63-6 |
| Formula | C16H13N8O19P3·C24H64N4 |
| Solubility | Soluble in H2O |
| Chemical Name | tetrakis(triethylamine) ((3a'R,4'R,6'R,6a'R)-4'-(6-amino-9H-purin-9-yl)-2,4,6-trinitro-3a',4',6',6a'-tetrahydrospiro[cyclohexa[2,4]diene-1,2'-furo[3,4-d][1,3]dioxol]-6'-yl)methyl triphosphate |
| Canonical SMILES | NC1=C(N=CN2[C@@]3([H])[C@@](O4)([H])[C@@](OC54C(N(=O)=O)([H])C=C(N(=O)=O)C=C5N(=O)=O)([H])[C@@](O3)([H])COP(O)(OP(O)(OP(O)(O)=O)=O)=O)C2=NC=N1.CCN(CC)CC.CCN(CC)CC.CCN(CC)CC.CCN(CC)CC |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
