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Pregnenolone Carbonitrile

Catalog No.
C3884
rodent pregnane X receptor (PXR) agonist
Grouped product items
SizePriceStock Qty
50mg
$87.00
In stock
100mg
$151.00
In stock
250mg
$298.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

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Background

Pregnenolone Carbonitrile (CAS 1434-54-4), known as Pregnenolone-16α-carbonitrile (PCN), is a pregnane X receptor (PXR) agonist primarily utilized in biomedical research investigating xenobiotic metabolism pathways. By activating rodent nuclear PXR, PCN stimulates expression of cytochrome P450 enzymes, notably of the CYP3A subfamily, enhancing hepatic detoxification and clearance of diverse foreign substances. Independently of PXR, PCN exhibits antifibrotic activity in liver fibrosis models, shown by inhibition of hepatic stellate cell trans-differentiation in vitro and decreased hepatic fibrosis in vivo. PCN thus serves as a useful tool for studying both PXR-dependent gene regulatory mechanisms and PXR-independent anti-fibrogenic effects.

Product Citation

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt341.5
Cas No.1434-54-4
FormulaC22H31NO2
SynonymsPCN,Pregnenolone 16α-carbonitrile,SC-4674
Solubilityinsoluble in H2O; insoluble in EtOH; ≥14.17 mg/mL in DMSO
Chemical Name3β-hydroxy-20-oxo-pregn-5-ene-16α-carbonitrile
SDFDownload SDF
Canonical SMILESO[C@H](C1)CC[C@@]2(C)C1=CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])C[C@@H](C#N)[C@@H]4C(C)=O
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

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Chemical structure

Pregnenolone Carbonitrile

相关生物数据

Pregnenolone Carbonitrile