PDD00017273
Catalog No.
B8394
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PDD00017273 is a potent and selective poly (ADP ribose) glycohydrolase (PARG) inhibitor with IC50 of 26 nM and KD value of 1.45 nM. PDD00017273 is 350 times more selective for PARG on a series of ion channels, enzymes and receptors including PARP1 and ARH3.PDD 00017273 (10 μM) does not inhibit five common Cytochrome P450 enzymes. PDD 00017273 (30 μM) modestly increasess phosphorylated H2AX (γH2AX) intensity.PDD 00017273 also decreases in NAD/H activity through PARG inhibition after DNA damage.
| Storage | Store at -20°C |
| M.Wt | 514.62 |
| Cas No. | 1945950-21-9 |
| Formula | C23H26N6O4S2 |
| Solubility | ≥52.2 mg/mL in DMSO with ultrasonic; insoluble in EtOH; insoluble in H2O |
| Chemical Name | 1-((1,3-dimethyl-1H-pyrazol-5-yl)methyl)-N-(1-methylcyclopropyl)-3-((2-methylthiazol-5-yl)methyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide |
| Canonical SMILES | O=C(N(CC1=CN=C(C)S1)C(N2CC3=CC(C)=NN3C)=O)C4=C2C=CC(S(NC5(CC5)C)(=O)=O)=C4 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
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