Nicotinamide
Nicotinamide (CAS: 98-92-0) is a small-molecule inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1), an enzyme critical in DNA repair pathways. Under pathological conditions such as ischemia or trauma, PARP-1 hyperactivation depletes cellular NAD+, triggering neuronal cell death. In vitro studies indicate that transporter-mediated uptake of nicotinamide confers protection against PARP-1-induced astrocyte injury. In vivo studies in diabetic rat models demonstrate that nicotinamide administration normalizes hepatic antioxidant enzymes, reducing oxidative stress. Clinical trials have shown dose-dependent upregulation of frataxin expression following sustained nicotinamide treatment, suggesting therapeutic potential in disorders like Friedreich's ataxia.
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| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 122.13 |
| Cas No. | 98-92-0 |
| Formula | C6H6N2O |
| Solubility | ≥13.75 mg/mL in EtOH; ≥29.75 mg/mL in H2O; ≥5.95 mg/mL in DMSO |
| Chemical Name | pyridine-3-carboxamide |
| SDF | Download SDF |
| Canonical SMILES | C1=CC(=CN=C1)C(=O)N |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
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