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MitoSOX Red

Catalog No.
B8808
A red-fluorescent probe for the selective detection of superoxide in the mitochondria
Grouped product items
SizePriceStock Qty
50ug
$52.00
In stock
1mg
$380.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

MitoSOX Red (CAS 1003197-00-9), also referred to as Mito-HE, is a fluorescent probe specifically developed for detecting mitochondrial superoxide in live cell studies. Upon cellular entry, it preferentially accumulates into mitochondria, where it is oxidized exclusively by superoxide radicals, resulting in emission of red fluorescence. Importantly, this reaction is selective, distinguishing mitochondrial superoxide from other reactive oxygen species (ROS) and reactive nitrogen species (RNS). The probe's oxidation can be inhibited by superoxide dismutase (SOD) or superoxide scavengers. Hence, MitoSOX Red serves as a valuable reagent for studying mitochondrial oxidative stress and evaluating superoxide levels in biological research contexts.

Description

MitoSOX Red, also called Mito-HE, is a novel probe for the selective detection of superoxide in the mitochondria of live cells. MitoSOX Red is live-cell permeant that selectively targets the mitochondria. Once in the mitochondria, MitoSOX can be oxidized by superoxide and exhibits bright red fluorescence. MitoSOX is oxidized by superoxide but not by other reactive oxygen species (ROS) or reactive nitrogen species (RNS), indicating that it is superoxide-specific. Meanwhile, oxidation of this probe can be prevented by superoxide dismutase (SOD) as well as superoxide scavengers.

Properties

Ex/Em 396/610
Synonyms Mito-HE
Storage The product should be stored at -20°C away from light and moisture.
Shipping Condition Blue ice
EXP Date The product should be stored at -20°C away from light and moisture. Stable for 1 year.

Chemical Properties

Physical AppearanceSolid
M.Wt759.70
Cas No.1003197-00-9
FormulaC43H43IN3P
Solubility≥50.6 mg/mL in DMSO; ≥10.22 mg/mL in EtOH with ultrasonic; insoluble in H2O
Chemical Name(6-(3,8-diamino-6-phenylphenanthridin-5(6H)-yl)hexyl)triphenylphosphonium iodide
SDFDownload SDF
Canonical SMILESNC1=CC(C(C2=CC=CC=C2)N(CCCCCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)C6=CC(N)=CC=C67)=C7C=C1.[I-]
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & DataSheet

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Components and Storage

Components B8808-50 ug B8808-1 mg
MitoSOX Red 50 ug 1 mg

The product should be stored at -20°C away from light and moisture. Stable for 1 year.