Ibotenic acid
Catalog No.
B6246
NMDA and metabotropic glutamate receptor agonist
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Ibotenic acid (CAS 2552-55-8) is a small-molecule agonist targeting N-methyl-D-aspartate (NMDA) and metabotropic glutamate receptors. Through receptor-mediated modulation of glutamatergic signaling pathways, ibotenic acid induces alterations in neuronal activity. In neuroscience research, it is commonly utilized to establish animal models of neurodegenerative disorders and to investigate underlying neural mechanisms of disease states.
- 1. Jin Ke, Wei-Cheng Lu, et al. "Functional dissection of parabrachial substrates in processing nociceptive information." Zool Res. 2024 May 18;45(3):633-647 PMID: 38766746
- 2. Alexander Dushkov, Zuzana Vosáhlová, et al. "Analysis of the Ibotenic Acid, Muscimol, and Ergosterol Content of an Amanita Muscaria Hydroalcoholic Extract with an Evaluation of Its Cytotoxic Effect against a Panel of Lung Cell Lines In Vitro." Molecules. 2023 Sep 27;28(19):6824. PMID: 37836667
- 3. Jiantao Huo, Feng Du, et al. "Identification of brain-to-spinal circuits controlling the laterality and duration of mechanical allodynia in mice." Cell Rep. 2023 Apr 25;42(4):112300. PMID: 36952340
| Physical Appearance | A white to off- |
| Storage | Desiccate at -20°C |
| M.Wt | 158.11 |
| Cas No. | 2552-55-8 |
| Formula | C5H6N2O4 |
| Solubility | insoluble in EtOH; ≥2.96 mg/mL in H2O with ultrasonic; ≥3.34 mg/mL in DMSO with gentle warming and ultrasonic |
| Chemical Name | (S)-2-amino-2-(3-oxo-2,3-dihydroisoxazol-5-yl)acetic acid |
| SDF | Download SDF |
| Canonical SMILES | OC([C@H](C(ON1)=CC1=O)N)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
