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GGsTop

Catalog No.
B5602
γ-glutamyl transpeptidase (GGT) inhibitor, novel and irreversible
Grouped product items
SizePriceStock Qty
10mg
$599.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

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Background

GGsTop (CAS 926281-37-0) is a selective, irreversible inhibitor targeting the enzyme γ-glutamyl transpeptidase (GGT), with a reported Ki of 0.17 mM. GGT regulates extracellular glutathione (GSH) homeostasis via cleavage of γ-glutamyl peptide bonds. GGsTop inhibits GGT activity in both bacterial (E. coli) and human systems. In animal studies, GGsTop administration led to increased lung lining fluid GSH levels, reduced airway mucus accumulation, and lowered airway hyperresponsiveness, suggesting therapeutic relevance to inflammation-related oxidative lung injury models. Additionally, GGsTop alleviated renal tissue damage and improved renal function in ischemia/reperfusion-induced acute kidney injury models in rats.

Product Citation

Chemical Properties

Physical AppearanceWhite solid
StorageStore at -20°C
M.Wt331.26
Cas No.926281-37-0
FormulaC13H18NO7P
Solubility<6.63mg/ml in H2O; <16.56mg/ml in DMSO
Chemical Name(S)-2-amino-4-((S)-(3-(carboxymethyl)phenoxy)(methoxy)phosphoryl)butanoic acid
SDFDownload SDF
Canonical SMILESO=[P@](OC)(CC[C@@H](C(O)=O)N)OC1=CC=CC(CC(O)=O)=C1
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

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Chemical structure

GGsTop

Related Biological Data

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Related Biological Data

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Related Biological Data

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