GGsTop
Catalog No.
B5602
γ-glutamyl transpeptidase (GGT) inhibitor, novel and irreversible
Featured Products
GGsTop (CAS 926281-37-0) is a selective, irreversible inhibitor targeting the enzyme γ-glutamyl transpeptidase (GGT), with a reported Ki of 0.17 mM. GGT regulates extracellular glutathione (GSH) homeostasis via cleavage of γ-glutamyl peptide bonds. GGsTop inhibits GGT activity in both bacterial (E. coli) and human systems. In animal studies, GGsTop administration led to increased lung lining fluid GSH levels, reduced airway mucus accumulation, and lowered airway hyperresponsiveness, suggesting therapeutic relevance to inflammation-related oxidative lung injury models. Additionally, GGsTop alleviated renal tissue damage and improved renal function in ischemia/reperfusion-induced acute kidney injury models in rats.
- 1. Jian Li, Tingting Wang, et al. "Activatable Dual ROS-Producing Probe for Dual Organelle-Engaged Photodynamic Therapy." ACS Appl Bio Mater. 2021 May 17;4(5):4618-4628. PMID:35006799
- 2. Jia-Ru Wei, Jun Dong, et al. "Cancer-associated fibroblasts-derived gamma-glutamyltransferase 5 promotes tumor growth and drug resistance in lung adenocarcinoma." Aging (Albany NY). 2020 Jul 8;12(13):13220-13233. PMID:32640421
- 3. LeiJianga, DanGuoa, et al. "Sensitive and selective SERS probe for detecting the activity of γ-glutamyl transpeptidase in serum." Analytica Chimica Acta. Available online 21 November 2019.
Physical Appearance | White solid |
Storage | Store at -20°C |
M.Wt | 331.26 |
Cas No. | 926281-37-0 |
Formula | C13H18NO7P |
Solubility | <6.63mg/ml in H2O; <16.56mg/ml in DMSO |
Chemical Name | (S)-2-amino-4-((S)-(3-(carboxymethyl)phenoxy)(methoxy)phosphoryl)butanoic acid |
SDF | Download SDF |
Canonical SMILES | O=[P@](OC)(CC[C@@H](C(O)=O)N)OC1=CC=CC(CC(O)=O)=C1 |
Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
- Datasheet
Chemical structure

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