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Cy5.5 carboxylic acid (non-sulfonated)

Catalog No.
A8134
Non-reactive fluorophore, for control experiments, and for calibration
Grouped product items
SizePriceStock Qty
5mg
$210.00
In stock
25mg
$410.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

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Background

Cy5.5 carboxylic acid is an un-activated labeling regent which has low aqueous solubility. For biomolecule labeling, the labeling reagent has low aqueous solubility, using of organic co-solvent to dissolve this molecular is necessary for efficient reaction. First, Cyanine dye should be dissolved in organic solvent and then added to a solution of biomolecule in appropriate aqueous buffer.

Cyanine 5.5 carboxylic acid instead of the drug was injected into the tumors in order to visually observe the dye release by using the in vivo imaging system (IVIS). Research show that NIR irradiation could efficiently triggered drug release from the DEPt-PEG/α-CD hydrogel in vivo [1].

Reference:
[1] Wang, X. ; Wang, C.; Zhang, Q.; Cheng, Y. Near Infrared Light-responsive and Injectable Supramolecular Hydrogels for On-demand Drug Delivery. Chemical Communications, 2016, 52, 978–981.

Chemical Properties

Physical AppearanceA solid
Storage24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
M.Wt619.23
FormulaC40H43ClN2O2
Solubilityinsoluble in H2O; ≥16.73 mg/mL in EtOH with ultrasonic; ≥213 mg/mL in DMSO
Chemical Name6-[(2E)-1,1-dimethyl-2-[(2E,4E)-5-(1,1,3-trimethylbenzo[e]indol-3-ium-2-yl)penta-2,4-dienylidene]benzo[e]indol-3-yl]hexanoic acid
SDFDownload SDF
Canonical SMILESCC1(C(=[N+](C2=C1C3=CC=CC=C3C=C2)C)C=CC=CC=C4C(C5=C(N4CCCCCC(=O)O)C=CC6=CC=CC=C65)(C)C)C
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Spectral properties

Excitation max (nm) 684 Emission max (nm) 710
Extinction Coefficient (M-1cm-1) 209000 Quantum Yield 0.2
CF260 0.07 CF280 0.03

Quality Control

Chemical structure

Cy5.5 carboxylic acid (non-sulfonated)

Related Biological Data

Cy5.5 carboxylic acid (non-sulfonated)