2-Chlorotrityl Chloride Resin

2-Chlorotrityl chloride resin (CAS 934816-82-7) is a chloromethyl-based polymer utilized commonly in solid-phase organic synthesis and peptide synthesis. Its structure comprises a reactive chlorotrityl chloride functionality that can link to carboxylic acids or other nucleophiles, forming ester or ether bonds. This covalent attachment provides stability throughout synthesis reactions, protecting molecules from side reactions or degradation. Upon reaction completion, target molecules are released with mild acidic cleavage conditions, allowing isolation of intact compounds. Frequently employed in methodologies for peptide assembly, small-molecule library synthesis for drug screening, and intermediate preparation in organic synthesis, this resin enables rapid molecular assembly and gentle release conditions.