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CK 666

Catalog No.
B5500
Arp2/3 complex inhibitor that inhibits actin polymerization
Grouped product items
SizePriceStock Qty
10mg
$209.00
In stock
50mg
$848.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

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Background

CK 666 (CAS 442633-00-3) is a cell-permeable small molecule inhibitor targeting the actin-related protein 2/3 (Arp2/3) complex. It functions by specifically binding to the Arp2/3 complex and stabilizing it in an inactive conformation, thereby preventing structural rearrangements necessary for Arp2 and Arp3 subunit activation. This inhibition consequently blocks the nucleation and branching of actin filaments. CK 666 is commonly utilized in studies investigating actin cytoskeleton dynamics, including cellular migration, intracellular trafficking, and morphological regulation processes mediated by Arp2/3.

Chemical Properties

Physical AppearanceOff White solid
StorageStore at -20°C
M.Wt296.34
Cas No.442633-00-3
FormulaC18H17FN2O
Solubility≥56.3 mg/mL in DMSO; ≥52.1 mg/mL in EtOH; insoluble in H2O
Chemical Name2-fluoro-N-(2-(2-methyl-1H-indol-3-yl)ethyl)benzamide
SDFDownload SDF
Canonical SMILESFC1=CC=CC=C1C(NCCC2=C(C)NC3=CC=CC=C23)=O
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

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Chemical structure

CK 666