CK 666
Catalog No.
B5500
Arp2/3 complex inhibitor that inhibits actin polymerization
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CK 666 (CAS 442633-00-3) is a cell-permeable small molecule inhibitor targeting the actin-related protein 2/3 (Arp2/3) complex. It functions by specifically binding to the Arp2/3 complex and stabilizing it in an inactive conformation, thereby preventing structural rearrangements necessary for Arp2 and Arp3 subunit activation. This inhibition consequently blocks the nucleation and branching of actin filaments. CK 666 is commonly utilized in studies investigating actin cytoskeleton dynamics, including cellular migration, intracellular trafficking, and morphological regulation processes mediated by Arp2/3.
| Physical Appearance | Off White solid |
| Storage | Store at -20°C |
| M.Wt | 296.34 |
| Cas No. | 442633-00-3 |
| Formula | C18H17FN2O |
| Solubility | ≥56.3 mg/mL in DMSO; ≥52.1 mg/mL in EtOH; insoluble in H2O |
| Chemical Name | 2-fluoro-N-(2-(2-methyl-1H-indol-3-yl)ethyl)benzamide |
| SDF | Download SDF |
| Canonical SMILES | FC1=CC=CC=C1C(NCCC2=C(C)NC3=CC=CC=C23)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
