Angiotensin 1/2 (1-6)
Angiotensin 1/2 (1-6) (CAS: 47896-63-9) is a hexapeptide fragment (Asp-Arg-Val-Tyr-Ile-His) derived from the N-terminal sequence of angiotensin I and II. This peptide is generated through proteolytic processing of angiotensinogen—a liver-produced glycoprotein—via renin and angiotensin-converting enzymes within the renin-angiotensin system. Angiotensin peptides modulate vascular tone by inducing vasoconstriction and promoting aldosterone release, resulting in increased blood pressure and sodium retention. Angiotensin 1/2 (1-6) is utilized in biomedical research to investigate the physiological and pathophysiological roles of angiotensin fragments in cardiovascular and renal regulation.
References:
1. Basso N, Terragno NA (December 2001). "History about the discovery of the renin-angiotensin system". Hypertension 38 (6): 1246–9.
2. Richard A. Preston. et. (1998). “Age-Race Subgroup Compared With Renin Profile as Predictors of Blood Pressure Response to Antihypertensive Therapy”. JAMA. 1998;280(13):1168-1172.
3. Williams GH, Dluhy RG (2008). "Chapter 336: Disorders of the Adrenal Cortex". In Loscalzo J, Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL. Harrison's principles of internal medicine. McGraw-Hill Medical.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 801.89 |
| Cas No. | 47896-63-9 |
| Formula | C36H55N11O10 |
| Synonyms | H2N-Asp-Arg-Val-Tyr-Ile-His-OH |
| Solubility | insoluble in EtOH; ≥62.4 mg/mL in H2O; ≥80.2 mg/mL in DMSO |
| Chemical Name | 2-amino-4,6-dimethyl-3-oxo-1-N,9-N-bis[(3R,6S,7S,10S,16S)-7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]phenoxazine-1,9-dicarboxamide |
| SDF | Download SDF |
| Canonical SMILES | CC1C(C(=O)NC(C(=O)N2CCCC2C(=O)N(CC(=O)N(C(C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)NC6C(OC(=O)C(N(C(=O)CN(C(=O)C7CCCN7C(=O)C(NC6=O)C(C)C)C)C)C(C)C)C)N)C |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
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Chemical structure
