Ac-YVAD-CMK
Catalog No.
C4810
Selectively inhibits Caspase-1, blocking pyroptosis and the release of inflammatory cytokines.
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Ac-YVAD-cmk is a selective caspase-1 (Caspase-1, also known as IL-1β converting enzyme, ICE) inhibitor and a research tool compound for the pyroptosis pathway. This inhibitor irreversibly binds to the active site of Caspase-1, thereby blocking the maturation and release of inflammatory cytokines such as IL-1β and IL-18, exerting anti-inflammatory and neuroprotective effects. In biomedical research, Ac-YVAD-cmk is commonly used in studies on inflammatory responses, neurodegenerative lesions and the pathogenesis of related diseases, as well as regulatory mechanisms of apoptosis and pyroptosis pathways.
| Physical Appearance | A solid |
| Storage | -20°C |
| M.Wt | 540.99 |
| Cas No. | 178603-78-6 |
| Formula | C24H33ClN4O8 |
| Synonyms | N-Ac-Tyr-Val-Ala-Asp-CMK |
| Solubility | ≤20mg/ml in DMSO;10mg/ml in dimethyl formamide |
| Chemical Name | (4S,7S,10S,13S)-13-(2-chloroacetyl)-4-(4-hydroxybenzyl)-7-isopropyl-10-methyl-2,5,8,11-tetraoxo-3,6,9,12-tetraazapentadecan-15-oic acid |
| Canonical SMILES | ClCC([C@@H](NC([C@@H](NC([C@H](C(C)C)NC([C@H](CC1=CC=C(O)C=C1)NC(C)=O)=O)=O)C)=O)CC(O)=O)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |