Verbascoside
Verbascoside (CAS: 61276-17-3) is a small-molecule inhibitor targeting protein kinase C (PKC) and the NF-κB signaling pathway.
Verbascoside exerts its biological activity primarily through the inhibition of PKC and suppression of NF-κB DNA-binding activation. In cell-based studies, Verbascoside demonstrates inhibitory activity, with an IC50 value of approximately 4.8 μM in RANKL-treated RAW264.7 cells and bone marrow macrophages (BMMs).
Verbascoside is utilized in the investigation of PKC/NF-κB-mediated signaling, osteoclastogenesis, and related cell signaling mechanisms.
References:
[1] Lee SY1, Lee KS, Yi SH, Kook SH, Lee JC. Acteoside suppresses RANKL-mediated osteoclastogenesis by inhibiting c-Fos induction and NF-κB pathway and attenuating ROS production. PLoS One. 2013 Dec 4;8(12):e80873. doi: 10.1371/journal.pone.0080873. eCollection 2013.
| Storage | Store at -20°C |
| M.Wt | 624.59 |
| Cas No. | 61276-17-3 |
| Formula | C29H36O15 |
| Solubility | insoluble in H2O; ≥30.95 mg/mL in DMSO; ≥63.6 mg/mL in EtOH |
| Chemical Name | [(2R,3R,4R,5R,6R)-6-[2-(3,4-dihydroxyphenyl)ethoxy]-5-hydroxy-2-(hydroxymethyl)-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate |
| SDF | Download SDF |
| Canonical SMILES | CC1C(C(C(C(O1)OC2C(C(OC(C2OC(=O)C=CC3=CC(=C(C=C3)O)O)CO)OCCC4=CC(=C(C=C4)O)O)O)O)O)O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
