Ro 31-8220 Mesylate
Ro 31-8220 Mesylate (CAS 138489-18-6) is a selective small molecule inhibitor of protein kinase C (PKC), targeting multiple PKC isoforms (α, βI, βII, γ, and ε) with IC50 values ranging from 5 to 27 nM. PKC constitutes a family of calcium- and phospholipid-dependent serine/threonine kinases implicated in signaling pathways associated with growth factor responses and malignant transformation. Ro 31-8220 modulates downstream targets, inhibiting MKP-1 and c-Fos expression while inducing c-Jun and activating Jun N-terminal kinase (JNK) in a PKC-dependent manner. It suppresses mitogen-induced IL-2 production and T-cell proliferation, suggesting utility in immunological research, and affects glucose metabolism via JNK and glycogen synthase activation, relevant to metabolic studies.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 553.65 |
| Cas No. | 138489-18-6 |
| Formula | C25H23N5O2S·CH4O3S |
| Solubility | ≥27.7 mg/mL in DMSO; insoluble in EtOH; ≥22.6 mg/mL in H2O |
| Chemical Name | methanesulfonic acid;3-[3-[4-(1-methylindol-3-yl)-2,5-dioxopyrrol-3-yl]indol-1-yl]propyl carbamimidothioate |
| SDF | Download SDF |
| Canonical SMILES | CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)CCCSC(=N)N.CS(=O)(=O)O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
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