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Ro 31-8220 Mesylate

Catalog No.
B2192
Pan-PKC inhibitor
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$160.00
In stock
10mg
$152.00
In stock
50mg
$439.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

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Background

Ro 31-8220 Mesylate (CAS 138489-18-6) is a selective small molecule inhibitor of protein kinase C (PKC), targeting multiple PKC isoforms (α, βI, βII, γ, and ε) with IC50 values ranging from 5 to 27 nM. PKC constitutes a family of calcium- and phospholipid-dependent serine/threonine kinases implicated in signaling pathways associated with growth factor responses and malignant transformation. Ro 31-8220 modulates downstream targets, inhibiting MKP-1 and c-Fos expression while inducing c-Jun and activating Jun N-terminal kinase (JNK) in a PKC-dependent manner. It suppresses mitogen-induced IL-2 production and T-cell proliferation, suggesting utility in immunological research, and affects glucose metabolism via JNK and glycogen synthase activation, relevant to metabolic studies.

Product Citation

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt553.65
Cas No.138489-18-6
FormulaC25H23N5O2S·CH4O3S
Solubility≥27.7 mg/mL in DMSO; insoluble in EtOH; ≥22.6 mg/mL in H2O
Chemical Namemethanesulfonic acid;3-[3-[4-(1-methylindol-3-yl)-2,5-dioxopyrrol-3-yl]indol-1-yl]propyl carbamimidothioate
SDFDownload SDF
Canonical SMILESCN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)CCCSC(=N)N.CS(=O)(=O)O
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Chemical structure

Ro 31-8220 Mesylate

Related Biological Data

Ro 31-8220 Mesylate