Tilorone (hydrochloride)
Tilorone (hydrochloride) (CAS No.: 27591-69-1) is a synthetic, orally bioavailable small-molecule interferon inducer broadly used in antiviral and immunomodulatory research. It functions primarily by stimulating host innate immune pathways, leading to enhanced production of type I interferons and activation of downstream antiviral signaling cascades, which collectively contribute to its broad-spectrum antiviral activity. Tilorone (hydrochloride) has demonstrated efficacy against multiple viral pathogens, including severe fever with thrombocytopenia syndrome virus in both in vitro and in vivo models, and exhibits inhibitory activity against Ebola virus in the nanomolar range, highlighting its potency in viral replication suppression. Notably, the compound is capable of penetrating the blood-brain barrier, enabling modulation of immune responses within the central nervous system and supporting its investigation in neurotropic viral infections and neuroinflammatory conditions. In addition to antiviral effects, it has been reported to exert anti-inflammatory, antitumor, and neuroprotective activities, potentially linked to its regulation of interferon-mediated and lysosomal pathways, including the induction of lysosomal glycosaminoglycan accumulation upon prolonged exposure. Tilorone (hydrochloride) is widely applied in cellular and animal models to study host-directed antiviral mechanisms and immune activation, with experimental dosing and concentration ranges varying depending on specific assay systems and research objectives.
| Physical Appearance | A solid |
| Storage | -20°C |
| M.Wt | 483.47 |
| Cas No. | 27591-69-1 |
| Formula | C25H36Cl2N2O3 |
| Synonyms | NSC 143969 |
| Solubility | ≥10.08 mg/mL in DMSO with ultrasonic; ≥9.86 mg/mL in EtOH with ultrasonic; ≥25.9 mg/mL in H2O |
| Chemical Name | 2,7-bis(2-(diethylamino)ethoxy)-9H-fluoren-9-one dihydrochloride |
| Canonical SMILES | O[C@@H]1[C@H]([C@H]([C@H](O[C@H]1O[C@@]([H])([C@@H]([C@H](C=O)O)O)[C@@H](CO)O)CO[C@]2(O[C@]([H])([C@@H]([C@H](C2)O)NC(C)=O)[C@H](O)[C@@H](CO)O)C([O-])=O)O)O.[Na+] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |